DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CPH
CGC
Degron:
PATTT
Uniprot ID:
O43670
Source protein:
BUB3-interacting and GLEBS motif-containing protein ZNF207
Source gene:
ZNF207
Class:
DEG_SPOP_SBC_1
Location:
311:315
E3 ligase:
SPOP
DEGRON score:
0.8955
ASA_SCORE:
90.9
COIL:
0.9534
CONS_SCORE:
0.2978
DSS_SCORE:
0.6853
HELIX:
0.019
FCONS_SCORE:
0.9988
RIG_SCORE:
0.6387
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T313K
DO16240
KIRC
ICGC
PATTT
DEG_SPOP_SBC_1
0.7306
p.A313T
PL18
pancreas
COSMIC
PATTT
DEG_SPOP_SBC_1
0.7139
p.P311T
DO37951
SKCM
ICGC
PATTT
DEG_SPOP_SBC_1
0.7031
p.A312S
DO229036
LICA
ICGC
PATTT
DEG_SPOP_SBC_1
0.6477
p.A306S
TCGA-AX-A06F
UCEC
TCGA
PATTT
DEG_SPOP_SBC_1
0.1944
p.F304L
DO222843
MELA
ICGC
PATTT
DEG_SPOP_SBC_1
0.1389
p.S304N
SIDM00153
T-Lymphoblastic Leukemia
GDSC
PATTT
DEG_SPOP_SBC_1
0.1389
p.S304N
ACH-000964
Leukemia
CCLE
PATTT
DEG_SPOP_SBC_1
0.1389
p.S325N
TCGA-AP-A059
UCEC
TCGA
PATTT
DEG_SPOP_SBC_1
0.0556
p.Y325H
DO225249
BRCA
ICGC
PATTT
DEG_SPOP_SBC_1
0.0556
Showing 1 to 10 of 10 entries
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Drug responses associated with ZNF207 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PATTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
1537:1541
PATTT
SPOP
0.9939
More...
Q9NZM4
BRD4-interacting chromatin-remodeling complex-associated protein
DEG_SPOP_SBC_1
428:432
PATTT
SPOP
0.947
More...
P51587
Breast cancer type 2 susceptibility protein
DEG_SPOP_SBC_1
564:568
PATTT
SPOP
0.9146
More...
O43670
BUB3-interacting and GLEBS motif-containing protein ZNF207
DEG_SPOP_SBC_1
311:315
PATTT
SPOP
0.8955
More...
Q9Y6J0
Calcineurin-binding protein cabin-1
DEG_SPOP_SBC_1
1824:1828
PATTT
SPOP
0.9363
More...
Q03001
Dystonin
DEG_SPOP_SBC_1
7436:7440
PATTT
SPOP
0.9065
More...
Q86UK7
E3 ubiquitin-protein ligase ZNF598
DEG_SPOP_SBC_1
729:733
PATTT
SPOP
0.9959
More...
Q9H8Y8
Golgi reassembly-stacking protein 2
DEG_SPOP_SBC_1
397:401
PATTT
SPOP
0.999
More...
Q9H2X6
Homeodomain-interacting protein kinase 2
DEG_SPOP_SBC_1
62:66
PATTT
SPOP
0.9768
More...
Q9H422
Homeodomain-interacting protein kinase 3
DEG_SPOP_SBC_1
695:699
PATTT
SPOP
0.9941
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2539:2543
PATTT
SPOP
0.77
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7725:7729
PATTT
SPOP
0.9548
More...
Q9NYI0
PH and SEC7 domain-containing protein 3
DEG_SPOP_SBC_1
921:925
PATTT
SPOP
0.9983
More...
Q6ISU1
Pre T-cell antigen receptor alpha
DEG_SPOP_SBC_1
182:186
PATTT
SPOP
0.9264
More...
Q765P7
Protein MTSS 2
DEG_SPOP_SBC_1
313:317
PATTT
SPOP
0.6279
More...
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
DEG_SPOP_SBC_1
498:502
PATTT
SPOP
0.9968
More...
P31645
Sodium-dependent serotonin transporter
DEG_SPOP_SBC_1
64:68
PATTT
SPOP
0.7561
More...
Q9H7N4
Splicing factor, arginine/serine-rich 19
DEG_SPOP_SBC_1
1042:1046
PATTT
SPOP
0.8197
More...
Q8TAQ2
SWI/SNF complex subunit SMARCC2
DEG_SPOP_SBC_1
1148:1152
PATTT
SPOP
0.9655
More...
Q8N3V7
Synaptopodin
DEG_SPOP_SBC_1
407:411
PATTT
SPOP
0.998
More...
Q8N9I0
Synaptotagmin-2
DEG_SPOP_SBC_1
15:19
PATTT
SPOP
0.7121
More...
Q9H3S7
Tyrosine-protein phosphatase non-receptor type 23
DEG_SPOP_SBC_1
879:883
PATTT
SPOP
0.9977
More...
Q6EMK4
Vasorin
DEG_SPOP_SBC_1
350:354
PATTT
SPOP
0.9976
More...
Q9P1Z0
Zinc finger and BTB domain-containing protein 4
DEG_SPOP_SBC_1
78:82
PATTT
SPOP
0.9893
More...
Q96KR1
Zinc finger RNA-binding protein
DEG_SPOP_SBC_1
220:224
PATTT
SPOP
0.9942
More...
Showing 1 to 25 of 25 entries
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