DegronMD - Q03001(DST)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q2430R	TCGA-17-Z042	LUAD	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2778
p.E2419G	TCGA-AG-3892	READ	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.25
p.L2689R	TCGA-AX-A063	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1667
p.T537I	TCGA-B5-A11E	UCEC	TCGA	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.T537I	TCGA-B5-A11E	UCEC	TCGA	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0556
p.T537I	DO41644	UCEC	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.T537I	DO41644	UCEC	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0556
p.M525I	TCGA-BP-4801	KIRC	TCGA	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.3056
p.M525I	DO18066	KIRC	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.3056
p.K1142T	TCGA-BS-A0UF	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.7306
p.E527K	TCGA-C5-A1BJ	CESC	TCGA	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation altering degron motif	0.7022
p.E527K	DO49009	CESC	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation altering degron motif	0.7022
p.F1145L	TCGA-DF-A2KV	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.E1138Q	TCGA-DK-A2I4	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.6744
p.N2686K	TCGA-EI-7002	READ	TCGA	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.0833
p.K2413T	TCGA-EO-A3AY	UCEC	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.0833
p.P1144S	TCGA-ER-A193	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2778
p.L1134F	TCGA-ER-A19K	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.K2416N	TCGA-FS-A1ZB	SKCM	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.1667
p.S2431L	TCGA-LL-A73Y	BRCA	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.25
p.I1130V	TCGA-UF-A7J9	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1111
p.D1136N	TCGA-W3-AA1V	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2778
p.S1140F	DO223592	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.7982
p.D2432N	DO524	BLCA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.D2432N	DO38006	SKCM	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.T2709I	DO785	BLCA	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.0556
p.S1148A	DO225048	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1667
p.S550F	DO228331	BRCA	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation altering degron motif	0.6871
p.K2414T	DO9002	COAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.1111
p.D2413G	DO7997	COAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.0833
p.P2424T	DO222794	COCA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7031
p.K1133E	DO233695	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.T2421A	DO233919	GACA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.3056
p.N2419Y	DO11100	GBM	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.25
p.P560S	DO12712	GBM	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.1111
p.G538D	DO10880	GBM	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1389
p.G538D	DO10880	GBM	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0833
p.T2690A	DO44440	HNSC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1944
p.D557E	DO228952	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.1944
p.D2413E	DO228976	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.0833
p.A2435D	DO228986	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.1389
p.T2428K	DO229029	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7306
p.T2423N	DO229022	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7055
p.T1134K	DO229027	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.T552N	DO229037	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation altering degron motif	0.7055
p.A1128T	DO50970	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.T1137K	DO25228	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.3056
p.Q2686H	DO26270	LUAD	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.0833
p.G543V	DO231086	LUSC	ICGC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.2222
p.Q2433E	DO26423	LUSC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.1944
p.L2688V	DO52687	MALY	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1389
p.L2700F	DO222557	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.3056
p.L520F	DO232038	ORCA	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.Q2421H	DO29830	OV	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.3056
p.L2427P	DO220239	SARC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7582
p.P516H	DO47607	SKCM	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.0556
p.R2437W	DO38619	STAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.0833
p.K2704N	DO219773	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1944
p.N1133T	DO42312	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.L2700I	DO41020	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.3056
p.L2690M	DO41235	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1944
p.E2429K	DO41235	UCEC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.3056
p.L530I	DO42592	UCEC	ICGC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation altering degron motif	0.6063
p.E2704D	DO41331	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1944
p.L2424F	DO41331	UCEC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.6981
p.A2685V	DO42665	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.0556
p.F1136L	DO41379	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2778
p.G541V	SIDM00401	Melanoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.0556
p.G541V	SIDM00401	Melanoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.1667
p.G541V	RVH-421	skin	COSMIC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.0556
p.G541V	RVH-421	skin	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.1667
p.N1133Y	SIDM01261	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.N1133Y	ACH-002208	Breast Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.N1133Y	YMB-1-E	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.M538V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1389
p.M538V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0833
p.M538V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1389
p.M538V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0833
p.M1146V	SIDM01095	Rhabdomyosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.M1146V	SIDM01112	Osteosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.M1146V	SIDM00841	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.V1147I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.V1147I	ACH-002238	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.V1147I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1944
p.G2418V	SIDM00806	Osteosarcoma	GDSC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.G2418V	HOS	bone	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.Q544E	SIDM00870	Breast Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.25
p.Q544E	HCC202	breast	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.25
p.K1135R	SIDM00980	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.K1135R	ACH-000948	Gastric Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.K1135R	23132-87	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.R546C	ACH-000329	Brain Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.3056
p.R546C	ACH-000565	Colon/Colorectal Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.3056
p.R546C	RCM-1	large intestine	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.3056
p.R546C	CCF-STTG1	central nervous system	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.3056
p.C1141Y	ACH-000340	Non-Cancerous	CCLE	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.7087
p.T2688A	ACH-000811	Ovarian Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1389
p.T2688A	SK-OV-3	ovary	COSMIC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1389
p.D2418N	ACH-000855	Esophageal Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.D2418N	KYSE-150	oesophagus	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.D2418G	ACH-000961	Endometrial/Uterine Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.M1137I	ACH-000983	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.3056
p.M1137I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.3056
p.P7435S	ACH-000999	Colon/Colorectal Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	7436:7440	Mutation rewiring degron network	0.3056
p.P7435S	SNU-1040	large intestine	COSMIC	PATTT	DEG_SPOP_SBC_1	7436:7440	Mutation rewiring degron network	0.3056
p.P7429L	ACH-001196	Sarcoma	CCLE	PATTT	DEG_SPOP_SBC_1	7436:7440	Mutation rewiring degron network	0.1389
p.S520L	ACH-001395	Breast Cancer	CCLE	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.T523A	ACH-001740	Sarcoma	CCLE	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.25
p.R2422P	ACH-002107	Bone Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7512
p.R2422P	ES6	bone	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7512
p.S537F	ACH-002220	Lymphoma	CCLE	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.S537F	ACH-002220	Lymphoma	CCLE	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0556
p.S537F	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation rewiring degron network	0.1667
p.S537F	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.0556
p.P1144H	BL-41	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2778
p.R554W	SW1271	lung	COSMIC	LTPSVT	DEG_SCF_FBW7_1	547:552	Mutation rewiring degron network	0.2778
p.K2418R	JHOS-4	ovary	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.K2418R	MKN1	stomach	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.K2418R	OCUB-M	breast	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation rewiring degron network	0.2222
p.Q2706R	SW48	large intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	2695:2699	Mutation rewiring degron network	0.1389
p.T7445M	COR-L23	lung	COSMIC	PATTT	DEG_SPOP_SBC_1	7436:7440	Mutation rewiring degron network	0.1944
p.R528C	JHH-7	liver	COSMIC	LTPSLT	DEG_SCF_FBW7_1	526:531	Mutation altering degron motif	0.8301
p.E2423K	HCT-116	large intestine	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	2422:2428	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DST

UniProt ID: Q03001

Entrez ID: 667

Protein name: Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DST in