DegronMD

Uniprot ID: Q03001

Source protein: Dystonin

Source gene: DST

Class: DEG_SCF_FBW7_1

Location: 547:552

E3 ligase: FBXW7

DEGRON score: 0.9769

ASA_SCORE: 70.6

COIL: 0.7907

CONS_SCORE: 0.3024

DSS_SCORE: 0.4857

HELIX: 0.0493

FCONS_SCORE: 1.0931

RIG_SCORE: 0.6875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T537I	TCGA-B5-A11E	UCEC	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.0556
p.T537I	DO41644	UCEC	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.0556
p.S550F	DO228331	BRCA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.6871
p.P560S	DO12712	GBM	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.1111
p.G538D	DO10880	GBM	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.0833
p.D557E	DO228952	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.1944
p.T552N	DO229037	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.7055
p.G543V	DO231086	LUSC	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2222
p.G541V	SIDM00401	Melanoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.1667
p.G541V	RVH-421	skin	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.1667
p.M538V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.0833
p.M538V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.0833
p.Q544E	SIDM00870	Breast Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.25
p.Q544E	HCC202	breast	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.25
p.R546C	ACH-000329	Brain Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.R546C	ACH-000565	Colon/Colorectal Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.R546C	RCM-1	large_intestine	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.R546C	CCF-STTG1	central_nervous_system	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.S537F	ACH-002220	Lymphoma	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.0556
p.S537F	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.0556
p.R554W	SW1271	lung	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03001	Dystonin	DEG_SCF_FBW7_1	547:552	LTPSVT	FBXW7	0.9769	More...
Q7Z3K6	Mesoderm induction early response protein 3	DEG_SCF_FBW7_1	127:132	LTPSVT	FBXW7	0.9392	More...
Q8N344	Mesoderm induction early response protein 2	DEG_SCF_FBW7_1	146:151	LTPSVT	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons