DegronMD

Uniprot ID: Q8N344

Source protein: Mesoderm induction early response protein 2

Source gene: MIER2

Class: DEG_SCF_FBW7_1

Location: 146:151

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 76.1167

COIL: 0.8513

CONS_SCORE: 0.4764

DSS_SCORE: 0.7043

HELIX: 0.0952

FCONS_SCORE: 1.1124

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L158V	TCGA-CK-4951	COAD	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.1389
p.L158V	DO10582	COAD	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.1389
p.D145N	TCGA-EO-A22U	UCEC	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.D145N	DO220902	MELA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.D145N	DO43755	UCEC	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.D145N	SIDM00678	Bladder Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.D145N	SIDM01155	Glioma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.D145N	SW1088	central_nervous_system	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.E154K	DO230312	COCA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.25
p.E154K	DO233747	GACA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.25
p.H153N	DO228952	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2778
p.D144E	DO229015	LICA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2778
p.L158F	SIDM00185	Melanoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.1389
p.L158F	ACH-002152	Skin Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.1389
p.L158F	LB2518-MEL	skin	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.1389
p.Q140R	SIDM00441	Acute Myeloid Leukemia	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.1667
p.Q140R	SIDM00837	Colorectal Carcinoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.1667
p.S149F	SIDM01240	Melanoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.6871
p.S149F	ACH-001002	Skin Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.6871
p.S149F	451Lu	skin	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.6871
p.P148S	SIDM01191	Osteosarcoma	GDSC	LTPSVT	DEG_SCF_FBW7_1	0.6752
p.P148S	ACH-000364	Primary	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.6752
p.P148S	U-2-OS	bone	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.6752
p.F159L	ACH-000622	Brain Cancer	CCLE	LTPSVT	DEG_SCF_FBW7_1	0.1111
p.F159L	KNS-42	central_nervous_system	COSMIC	LTPSVT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03001	Dystonin	DEG_SCF_FBW7_1	547:552	LTPSVT	FBXW7	0.9769	More...
Q7Z3K6	Mesoderm induction early response protein 3	DEG_SCF_FBW7_1	127:132	LTPSVT	FBXW7	0.9392	More...
Q8N344	Mesoderm induction early response protein 2	DEG_SCF_FBW7_1	146:151	LTPSVT	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons