DegronMD

Uniprot ID: Q7Z3K6

Source protein: Mesoderm induction early response protein 3

Source gene: MIER3

Class: DEG_SCF_FBW7_1

Location: 127:132

E3 ligase: FBXW7

DEGRON score: 0.9392

ASA_SCORE: 78.0167

COIL: 0.9045

CONS_SCORE: 0.4274

DSS_SCORE: 0.6823

HELIX: 0.0353

FCONS_SCORE: 0.9915

RIG_SCORE: 0.6307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A124G	TCGA-13-2061	OV	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.25
p.D126N	TCGA-34-2600	LUSC	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.3056
p.P141S	TCGA-AX-A05Z	UCEC	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.0833
p.P141H	TCGA-D3-A2JL	SKCM	TCGA	LTPSVT	DEG_SCF_FBW7_1	0.0833
p.V136L	DO48576	BLCA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2222
p.E134Q	DO3001	BRCA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2778
p.E140K	DO233693	GACA	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.1111
p.D131N	DO44623	LGG	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.6932
p.V136I	DO38404	STAD	ICGC	LTPSVT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03001	Dystonin	DEG_SCF_FBW7_1	547:552	LTPSVT	FBXW7	0.9769	More...
Q7Z3K6	Mesoderm induction early response protein 3	DEG_SCF_FBW7_1	127:132	LTPSVT	FBXW7	0.9392	More...
Q8N344	Mesoderm induction early response protein 2	DEG_SCF_FBW7_1	146:151	LTPSVT	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons