DegronMD

Uniprot ID: Q03001

Source protein: Dystonin

Source gene: DST

Class: DEG_SCF_FBW7_1

Location: 526:531

E3 ligase: FBXW7

DEGRON score: 0.9503

ASA_SCORE: 70.7833

COIL: 0.705

CONS_SCORE: 0.258

DSS_SCORE: 0.4722

HELIX: 0.2425

FCONS_SCORE: 1.0508

RIG_SCORE: 0.6888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T537I	TCGA-B5-A11E	UCEC	TCGA	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.T537I	DO41644	UCEC	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.M525I	TCGA-BP-4801	KIRC	TCGA	LTPSLT	DEG_SCF_FBW7_1	0.3056
p.M525I	DO18066	KIRC	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.3056
p.E527K	TCGA-C5-A1BJ	CESC	TCGA	LTPSLT	DEG_SCF_FBW7_1	0.7022
p.E527K	DO49009	CESC	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.7022
p.G538D	DO10880	GBM	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.1389
p.L520F	DO232038	ORCA	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.P516H	DO47607	SKCM	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.0556
p.L530I	DO42592	UCEC	ICGC	LTPSLT	DEG_SCF_FBW7_1	0.6063
p.G541V	SIDM00401	Melanoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	0.0556
p.G541V	RVH-421	skin	COSMIC	LTPSLT	DEG_SCF_FBW7_1	0.0556
p.M538V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	0.1389
p.M538V	SIDM00719	Small Cell Lung Carcinoma	GDSC	LTPSLT	DEG_SCF_FBW7_1	0.1389
p.S520L	ACH-001395	Breast Cancer	CCLE	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.T523A	ACH-001740	Sarcoma	CCLE	LTPSLT	DEG_SCF_FBW7_1	0.25
p.S537F	ACH-002220	Lymphoma	CCLE	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.S537F	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSLT	DEG_SCF_FBW7_1	0.1667
p.R528C	JHH-7	liver	COSMIC	LTPSLT	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03001	Dystonin	DEG_SCF_FBW7_1	526:531	LTPSLT	FBXW7	0.9503	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons