DegronMD

Uniprot ID: Q03001

Source protein: Dystonin

Source gene: DST

Class: DEG_APCC_KENBOX_2

Location: 2695:2699

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5258

ASA_SCORE: 85.36

COIL: 0.4528

CONS_SCORE: 0.3015

DSS_SCORE: 0.3854

HELIX: 0.485

FCONS_SCORE: 1.1253

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2689R	TCGA-AX-A063	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.1667
p.N2686K	TCGA-EI-7002	READ	TCGA	SKENL	DEG_APCC_KENBOX_2	0.0833
p.T2709I	DO785	BLCA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0556
p.T2690A	DO44440	HNSC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.Q2686H	DO26270	LUAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0833
p.L2688V	DO52687	MALY	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1389
p.L2700F	DO222557	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.3056
p.K2704N	DO219773	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.L2700I	DO41020	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.3056
p.L2690M	DO41235	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.E2704D	DO41331	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.A2685V	DO42665	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0556
p.T2688A	ACH-000811	Ovarian Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	0.1389
p.T2688A	SK-OV-3	ovary	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.1389
p.Q2706R	SW48	large_intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons