DegronMD

Uniprot ID: P42684

Source protein: Tyrosine-protein kinase ABL2

Source gene: ABL2

Class: DEG_APCC_KENBOX_2

Location: 97:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9858

ASA_SCORE: 89.38

COIL: 0.565

CONS_SCORE: 0.5335

DSS_SCORE: 0.3562

HELIX: 0.3968

FCONS_SCORE: 1.0544

RIG_SCORE: 0.7821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R94M	TCGA-86-8073	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.25
p.R94M	TCGA-A5-A0G1	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.25
p.K98M	TCGA-86-8585	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.8062
p.A88T	TCGA-B5-A0JY	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.0833
p.K98N	TCGA-BF-A1Q0	SKCM	TCGA	SKENL	DEG_APCC_KENBOX_2	0.6918
p.A88S	TCGA-DD-AADF	LIHC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.0833
p.E106K	TCGA-MP-A4SY	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.1944
p.R99Q	DO1749	BRCA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.7329
p.Y103C	DO8722	COAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.2778
p.D87G	DO44543	LGG	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0556
p.R99G	DO233491	PRAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.7568
p.Q105K	DO37946	SKCM	ICGC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.G102D	DO42568	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.3056
p.P109L	SIDM00571	Pancreatic Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.1111
p.P109L	ACH-000108	Pancreatic Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	0.1111
p.P109L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.1111
p.A104T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	0.25
p.P88L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.0833
p.P94L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons