DegronMD

Uniprot ID: O43660

Source protein: Pleiotropic regulator 1

Source gene: PLRG1

Class: DEG_APCC_KENBOX_2

Location: 61:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.982

ASA_SCORE: 76.58

COIL: 0.8818

CONS_SCORE: 0.5665

DSS_SCORE: 0.662

HELIX: 0.0836

FCONS_SCORE: 0.9581

RIG_SCORE: 0.677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H57N	TCGA-05-4396	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.2222
p.H57N	DO23838	LUAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.T74M	TCGA-CG-5721	STAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.0833
p.T74M	DO38192	STAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0833
p.Q71K	DO222647	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1667
p.P54L	DO222843	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1389
p.T74S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SKENL	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons