DegronMD - P42684(ABL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S564F	TCGA-04-1360	OV	TCGA	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.3056
p.L572I	TCGA-12-0778	GBM	TCGA	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.0833
p.S562L	TCGA-2W-A8YY	CESC	TCGA	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7667
p.S562L	SIDM00013	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7667
p.S562L	SIDM00500	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7667
p.S562L	ACH-000959	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7667
p.S562L	ACH-002387	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7667
p.T163N	TCGA-44-5644	LUAD	TCGA	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation altering degron motif	0.8166
p.N830Y	TCGA-49-6743	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0556
p.R571L	TCGA-64-1679	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1111
p.R94M	TCGA-86-8073	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.25
p.R94M	TCGA-A5-A0G1	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.25
p.K98M	TCGA-86-8585	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation altering degron motif	0.8062
p.S167N	TCGA-A6-6780	COAD	TCGA	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation altering degron motif	0.7069
p.G557E	TCGA-AA-3850	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2778
p.L168Q	TCGA-AJ-A3BG	UCEC	TCGA	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.3056
p.A88T	TCGA-B5-A0JY	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.0833
p.K98N	TCGA-BF-A1Q0	SKCM	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation altering degron motif	0.6918
p.A88S	TCGA-DD-AADF	LIHC	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.0833
p.P164S	TCGA-DU-6407	LGG	TCGA	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation altering degron motif	0.6752
p.S159N	TCGA-E7-A7DU	BLCA	TCGA	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation blocking phosphorylation signal	0.6944
p.S159N	SIDM00960	Colorectal Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation blocking phosphorylation signal	0.6944
p.S159N	ACH-000798	Colon/Colorectal Cancer	CCLE	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation blocking phosphorylation signal	0.6944
p.S159N	CL-40	large intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation blocking phosphorylation signal	0.6944
p.G594W	TCGA-EO-A22U	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2778
p.P822L	TCGA-ER-A42K	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.E106K	TCGA-MP-A4SY	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.1944
p.S174L	DO48368	BLCA	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation blocking phosphorylation signal	0.5833
p.R99Q	DO1749	BRCA	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation altering degron motif	0.7329
p.Y103C	DO8722	COAD	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.2778
p.S172P	DO233885	GACA	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.1944
p.G169W	DO44458	KIRC	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.2778
p.D87G	DO44543	LGG	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.0556
p.P168T	DO228952	LICA	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.3056
p.D806G	DO228850	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0556
p.F819L	DO229028	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.6981
p.F819L	DO219773	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.6981
p.P596T	DO229022	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.N555K	DO229035	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2222
p.Q826H	DO23705	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.N555S	DO51489	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.2222
p.R99G	DO233491	PRAD	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation altering degron motif	0.7568
p.S166N	DO36556	READ	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation altering degron motif	0.7069
p.R176M	DO227677	SKCA	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.0833
p.P168L	DO37819	SKCM	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.3056
p.P168S	DO37819	SKCM	ICGC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.3056
p.S568F	DO37782	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation blocking phosphorylation signal	0.6389
p.Q105K	DO37946	SKCM	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.2222
p.S829F	DO51276	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0833
p.S829F	DO38153	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0833
p.S829F	Mewo	skin	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0833
p.P596L	DO42033	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.R589Q	DO43186	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation altering degron motif	0.7329
p.G102D	DO42568	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.3056
p.T828A	DO43891	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1111
p.G558W	DO43755	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.3056
p.P109L	SIDM00571	Pancreatic Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.1111
p.P109L	ACH-000108	Pancreatic Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.1111
p.P109L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.1111
p.E824D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222
p.E824D	ACH-000929	Lung Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222
p.E824D	NCI-H2110	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222
p.A595S	SIDM00884	Breast Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.25
p.A595S	ACH-000699	Breast Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.25
p.A595S	HCC1395	breast	COSMIC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.25
p.R571Q	SIDM01619	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1111
p.R571Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	559:563	Mutation rewiring degron network	0.1111
p.A104T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.25
p.A559T	ACH-001521	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7139
p.P88L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.0833
p.E809D	NCI-H2110	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation blocking ubiquitination signal	0.5833
p.A559S	HCC1395	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	559:563	Mutation altering degron motif	0.7588
p.A826V	SW954	vulva	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.A168T	CW-2	large intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation rewiring degron network	0.3056
p.P94L	KP-3	pancreas	COSMIC	SKENL	DEG_APCC_KENBOX_2	97:101	Mutation rewiring degron network	0.25
p.T820P	EFO-27	ovary	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7031
p.A820V	SW954	vulva	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.6936
p.A580S	HCC1395	breast	COSMIC	NKENI	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.1111
p.A162T	CW-2	large intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	162:167	Mutation altering degron motif	0.7139
p.K818R	KP-N-YN	autonomic ganglia	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7237
p.T814P	EFO-27	ovary	COSMIC	VSTSS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778

Kaplan plot for ABL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABL2

UniProt ID: P42684

Entrez ID: 27

Protein name: Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABL2 in