DegronMD

Uniprot ID: P42684

Source protein: Tyrosine-protein kinase ABL2

Source gene: ABL2

Class: DEG_APCC_KENBOX_2

Location: 588:592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8172

ASA_SCORE: 111.44

COIL: 0.6846

CONS_SCORE: 0.3416

DSS_SCORE: 0.5686

HELIX: 0.2882

FCONS_SCORE: 0.9506

RIG_SCORE: 0.7406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G594W	TCGA-EO-A22U	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.2778
p.P596T	DO229022	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.2222
p.P596L	DO42033	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	0.2222
p.R589Q	DO43186	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	0.7329
p.A595S	SIDM00884	Breast Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.25
p.A595S	ACH-000699	Breast Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	0.25
p.A595S	HCC1395	breast	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.25
p.A580S	HCC1395	breast	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	588:592	NKENI	APC,CDC20,FZR1	0.8172	More...
Q96GX5	Serine/threonine-protein kinase greatwall	DEG_APCC_KENBOX_2	505:509	NKENI	APC,CDC20,FZR1	0.7264	More...
Q99700	Ataxin-2	DEG_APCC_KENBOX_2	762:766	NKENI	APC,CDC20,FZR1	0.9963	More...
Q9NYC9	Dynein axonemal heavy chain 9	DEG_APCC_KENBOX_2	3229:3233	NKENI	APC,CDC20,FZR1	0.5274	More...
Q6ZVT6	Protein CFAP20DC	DEG_APCC_KENBOX_2	199:203	NKENI	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons