DegronMD

Uniprot ID: Q96GX5

Source protein: Serine/threonine-protein kinase greatwall

Source gene: MASTL

Class: DEG_APCC_KENBOX_2

Location: 505:509

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7264

ASA_SCORE: 103.18

COIL: 0.5116

CONS_SCORE: 0.2806

DSS_SCORE: 0.4751

HELIX: 0.4666

FCONS_SCORE: 0.9579

RIG_SCORE: 0.7495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V510F	TCGA-13-0764	OV	TCGA	NKENI	DEG_APCC_KENBOX_2	0.3056
p.V510F	DO30930	OV	ICGC	NKENI	DEG_APCC_KENBOX_2	0.3056
p.D515N	TCGA-4Z-AA7S	BLCA	TCGA	NKENI	DEG_APCC_KENBOX_2	0.1667
p.D515N	DO218982	BLCA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.1667
p.S512Y	TCGA-B5-A3FC	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.6944
p.S512Y	TCGA-EO-A22X	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.6944
p.S512Y	DO41871	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	0.6944
p.S512Y	DO43907	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	0.6944
p.K497R	TCGA-C8-A12O	BRCA	TCGA	NKENI	DEG_APCC_KENBOX_2	0.5556
p.K497R	DO4677	BRCA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.5556
p.C503S	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.2778
p.C503S	ACH-000781	Lung Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	0.2778
p.C503S	NCI-H2023	lung	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.2778
p.C503G	SIDM01588	Endometrial Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.2778
p.C503G	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	588:592	NKENI	APC,CDC20,FZR1	0.8172	More...
Q96GX5	Serine/threonine-protein kinase greatwall	DEG_APCC_KENBOX_2	505:509	NKENI	APC,CDC20,FZR1	0.7264	More...
Q99700	Ataxin-2	DEG_APCC_KENBOX_2	762:766	NKENI	APC,CDC20,FZR1	0.9963	More...
Q9NYC9	Dynein axonemal heavy chain 9	DEG_APCC_KENBOX_2	3229:3233	NKENI	APC,CDC20,FZR1	0.5274	More...
Q6ZVT6	Protein CFAP20DC	DEG_APCC_KENBOX_2	199:203	NKENI	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons