DegronMD - Q9NYC9(DNAH9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1270Y	TCGA-44-6145	LUAD	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0556
p.S1270Y	TCGA-OR-A5KB	ACC	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0556
p.S1270Y	DO25123	LUAD	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0556
p.Q1294K	TCGA-77-8154	LUSC	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.1944
p.Q1294K	DO27224	LUSC	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.1944
p.P3243R	TCGA-99-8032	LUAD	TCGA	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.0556
p.P3243R	DO23765	LUAD	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.0556
p.K1297E	TCGA-AJ-A3EL	UCEC	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation substituting flanking lysine	0.2222
p.K1297E	DO41542	UCEC	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation substituting flanking lysine	0.2222
p.S1278F	TCGA-EB-A41A	SKCM	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2778
p.S1278F	DO37429	SKCM	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2778
p.S1276A	TCGA-EO-A22X	UCEC	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2222
p.S1276A	DO43907	UCEC	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2222
p.R3242K	TCGA-K4-A54R	BLCA	TCGA	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.0833
p.R3242K	DO48611	BLCA	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.0833
p.E3231K	TCGA-VS-A8EL	CESC	TCGA	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7022
p.E3231K	DO51624	CESC	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7022
p.E1298V	TCGA-XK-AAIW	PRAD	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0833
p.E1298V	DO51407	PRAD	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0833
p.S1276F	TCGA-YG-AA3N	SKCM	TCGA	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2222
p.S1276F	DO51298	SKCM	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.2222
p.K1297N	DO222762	COCA	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation substituting flanking lysine	0.2222
p.N3227H	DO222798	COCA	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.2778
p.E3231V	DO50452	ESAD	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7693
p.C3237F	DO229009	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.2222
p.G3220S	DO50970	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation rewiring degron network	0.0833
p.L1292Q	DO231830	LINC	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.25
p.E3231D	DO52670	MALY	ICGC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.6758
p.A1279S	DO32817	PACA	ICGC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.3056
p.A1279S	PANC-10-05	pancreas	COSMIC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.3056
p.V1299A	SIDM00845	Burkitt's Lymphoma	GDSC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.0556
p.E1277K	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.25
p.E1277K	ACH-000463	Lung Cancer	CCLE	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.25
p.E1277K	NCI-H460	lung	COSMIC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation rewiring degron network	0.25
p.N3232T	SIDM00317	Kidney Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7055
p.N3232T	ACH-000171	Kidney Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7055
p.N3232T	VMRC-RCZ	kidney	COSMIC	NKENI	DEG_APCC_KENBOX_2	3229:3233	Mutation altering degron motif	0.7055
p.F1282L	SIDM00251	Gastric Carcinoma	GDSC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation altering degron motif	0.587
p.F1282L	ACH-000949	Gastric Cancer	CCLE	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation altering degron motif	0.587
p.F1282L	TGBC11TKB	stomach	COSMIC	SLFEVNVPDY	DEG_COP1_1	1280:1289	Mutation altering degron motif	0.587

Kaplan plot for DNAH9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH9

UniProt ID: Q9NYC9

Entrez ID: 1770

Protein name: Dynein axonemal heavy chain 9 (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH9 in