DegronMD

Uniprot ID: Q9NYC9

Source protein: Dynein axonemal heavy chain 9

Source gene: DNAH9

Class: DEG_COP1_1

Location: 1280:1289

E3 ligase: COP1

DEGRON score: 0.9088

ASA_SCORE: 71.66

COIL: 0.6661

CONS_SCORE: 0.4496

DSS_SCORE: 0.2092

HELIX: 0.3252

FCONS_SCORE: 1.201

RIG_SCORE: 0.8023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1270Y	TCGA-44-6145	LUAD	TCGA	SLFEVNVPDY	DEG_COP1_1	0.0556
p.S1270Y	TCGA-OR-A5KB	ACC	TCGA	SLFEVNVPDY	DEG_COP1_1	0.0556
p.S1270Y	DO25123	LUAD	ICGC	SLFEVNVPDY	DEG_COP1_1	0.0556
p.Q1294K	TCGA-77-8154	LUSC	TCGA	SLFEVNVPDY	DEG_COP1_1	0.1944
p.Q1294K	DO27224	LUSC	ICGC	SLFEVNVPDY	DEG_COP1_1	0.1944
p.K1297E	TCGA-AJ-A3EL	UCEC	TCGA	SLFEVNVPDY	DEG_COP1_1	0.2222
p.K1297E	DO41542	UCEC	ICGC	SLFEVNVPDY	DEG_COP1_1	0.2222
p.S1278F	TCGA-EB-A41A	SKCM	TCGA	SLFEVNVPDY	DEG_COP1_1	0.2778
p.S1278F	DO37429	SKCM	ICGC	SLFEVNVPDY	DEG_COP1_1	0.2778
p.S1276A	TCGA-EO-A22X	UCEC	TCGA	SLFEVNVPDY	DEG_COP1_1	0.2222
p.S1276A	DO43907	UCEC	ICGC	SLFEVNVPDY	DEG_COP1_1	0.2222
p.E1298V	TCGA-XK-AAIW	PRAD	TCGA	SLFEVNVPDY	DEG_COP1_1	0.0833
p.E1298V	DO51407	PRAD	ICGC	SLFEVNVPDY	DEG_COP1_1	0.0833
p.S1276F	TCGA-YG-AA3N	SKCM	TCGA	SLFEVNVPDY	DEG_COP1_1	0.2222
p.S1276F	DO51298	SKCM	ICGC	SLFEVNVPDY	DEG_COP1_1	0.2222
p.K1297N	DO222762	COCA	ICGC	SLFEVNVPDY	DEG_COP1_1	0.2222
p.L1292Q	DO231830	LINC	ICGC	SLFEVNVPDY	DEG_COP1_1	0.25
p.A1279S	DO32817	PACA	ICGC	SLFEVNVPDY	DEG_COP1_1	0.3056
p.A1279S	PANC-10-05	pancreas	COSMIC	SLFEVNVPDY	DEG_COP1_1	0.3056
p.V1299A	SIDM00845	Burkitt's Lymphoma	GDSC	SLFEVNVPDY	DEG_COP1_1	0.0556
p.E1277K	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	SLFEVNVPDY	DEG_COP1_1	0.25
p.E1277K	ACH-000463	Lung Cancer	CCLE	SLFEVNVPDY	DEG_COP1_1	0.25
p.E1277K	NCI-H460	lung	COSMIC	SLFEVNVPDY	DEG_COP1_1	0.25
p.F1282L	SIDM00251	Gastric Carcinoma	GDSC	SLFEVNVPDY	DEG_COP1_1	0.587
p.F1282L	ACH-000949	Gastric Cancer	CCLE	SLFEVNVPDY	DEG_COP1_1	0.587
p.F1282L	TGBC11TKB	stomach	COSMIC	SLFEVNVPDY	DEG_COP1_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYC9	Dynein axonemal heavy chain 9	DEG_COP1_1	1280:1289	SLFEVNVPDY	COP1	0.9088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons