DegronMD

Uniprot ID: Q9NYC9

Source protein: Dynein axonemal heavy chain 9

Source gene: DNAH9

Class: DEG_APCC_KENBOX_2

Location: 3229:3233

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5274

ASA_SCORE: 80.22

COIL: 0.7288

CONS_SCORE: 0.548

DSS_SCORE: 0.1226

HELIX: 0.2704

FCONS_SCORE: 1.1321

RIG_SCORE: 0.8087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3243R	TCGA-99-8032	LUAD	TCGA	NKENI	DEG_APCC_KENBOX_2	0.0556
p.P3243R	DO23765	LUAD	ICGC	NKENI	DEG_APCC_KENBOX_2	0.0556
p.R3242K	TCGA-K4-A54R	BLCA	TCGA	NKENI	DEG_APCC_KENBOX_2	0.0833
p.R3242K	DO48611	BLCA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.0833
p.E3231K	TCGA-VS-A8EL	CESC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.7022
p.E3231K	DO51624	CESC	ICGC	NKENI	DEG_APCC_KENBOX_2	0.7022
p.N3227H	DO222798	COCA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.2778
p.E3231V	DO50452	ESAD	ICGC	NKENI	DEG_APCC_KENBOX_2	0.7693
p.C3237F	DO229009	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.2222
p.G3220S	DO50970	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.0833
p.E3231D	DO52670	MALY	ICGC	NKENI	DEG_APCC_KENBOX_2	0.6758
p.N3232T	SIDM00317	Kidney Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.7055
p.N3232T	ACH-000171	Kidney Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	0.7055
p.N3232T	VMRC-RCZ	kidney	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	588:592	NKENI	APC,CDC20,FZR1	0.8172	More...
Q96GX5	Serine/threonine-protein kinase greatwall	DEG_APCC_KENBOX_2	505:509	NKENI	APC,CDC20,FZR1	0.7264	More...
Q99700	Ataxin-2	DEG_APCC_KENBOX_2	762:766	NKENI	APC,CDC20,FZR1	0.9963	More...
Q9NYC9	Dynein axonemal heavy chain 9	DEG_APCC_KENBOX_2	3229:3233	NKENI	APC,CDC20,FZR1	0.5274	More...
Q6ZVT6	Protein CFAP20DC	DEG_APCC_KENBOX_2	199:203	NKENI	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons