DegronMD

Uniprot ID: Q99700

Source protein: Ataxin-2

Source gene: ATXN2

Class: DEG_APCC_KENBOX_2

Location: 762:766

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 117.88

COIL: 0.9178

CONS_SCORE: 0.3415

DSS_SCORE: 0.8192

HELIX: 0.0386

FCONS_SCORE: 1.086

RIG_SCORE: 0.5932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E764D	TCGA-AX-A1CE	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.6758
p.S776L	TCGA-EK-A3GK	CESC	TCGA	NKENI	DEG_APCC_KENBOX_2	0.5
p.K763N	TCGA-F5-6814	READ	TCGA	NKENI	DEG_APCC_KENBOX_2	0.6918
p.A766G	DO20932	KIRP	ICGC	NKENI	DEG_APCC_KENBOX_2	0.754
p.P768Q	DO229027	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.2778
p.T773K	DO229026	LICA	ICGC	NKENI	DEG_APCC_KENBOX_2	0.1389
p.T773M	DO47785	STAD	ICGC	NKENI	DEG_APCC_KENBOX_2	0.1389
p.N762I	SIDM01034	B-Lymphoblastic Leukemia	GDSC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	SIDM00585	Hepatocellular Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	SIDM00316	Glioblastoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	SIDM01394	Kidney Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	YH-13	central_nervous_system	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	HuH-7	liver	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.N762I	TE-15	oesophagus	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.6169
p.I766V	SIDM00845	Burkitt's Lymphoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.5965
p.N762S	SIDM00845	Burkitt's Lymphoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.5958
p.K763E	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.7022
p.K763E	NCI-H650	lung	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.7022
p.R755M	SIDM00214	Colorectal Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.1389
p.R755M	SNU-407	large_intestine	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.1389
p.P773H	SIDM01612	Endometrial Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	0.1389
p.T774A	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENI	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	588:592	NKENI	APC,CDC20,FZR1	0.8172	More...
Q96GX5	Serine/threonine-protein kinase greatwall	DEG_APCC_KENBOX_2	505:509	NKENI	APC,CDC20,FZR1	0.7264	More...
Q99700	Ataxin-2	DEG_APCC_KENBOX_2	762:766	NKENI	APC,CDC20,FZR1	0.9963	More...
Q9NYC9	Dynein axonemal heavy chain 9	DEG_APCC_KENBOX_2	3229:3233	NKENI	APC,CDC20,FZR1	0.5274	More...
Q6ZVT6	Protein CFAP20DC	DEG_APCC_KENBOX_2	199:203	NKENI	APC,CDC20,FZR1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENI

Degron related mutations and impact score

Drug responses associated with ATXN2 mutations

All proteins holding degron of NKENI