DegronMD - Q96GX5(MASTL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L438I	TCGA-06-A6S1	GBM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.L438I	DO50113	GBM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.V510F	TCGA-13-0764	OV	TCGA	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.3056
p.V510F	DO30930	OV	ICGC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.3056
p.D515N	TCGA-4Z-AA7S	BLCA	TCGA	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.1667
p.D515N	DO218982	BLCA	ICGC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.1667
p.G432E	TCGA-AA-3662	COAD	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation altering degron motif	0.6087
p.G432E	DO8336	COAD	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation altering degron motif	0.6087
p.Q425R	TCGA-AJ-A3EK	UCEC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.Q425R	DO41584	UCEC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.A427D	TCGA-AJ-A3EK	UCEC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2778
p.A427D	DO41584	UCEC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2778
p.S512Y	TCGA-B5-A3FC	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking phosphorylation signal	0.6944
p.S512Y	TCGA-EO-A22X	UCEC	TCGA	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking phosphorylation signal	0.6944
p.S512Y	DO41871	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking phosphorylation signal	0.6944
p.S512Y	DO43907	UCEC	ICGC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking phosphorylation signal	0.6944
p.K497R	TCGA-C8-A12O	BRCA	TCGA	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking ubiquitination signal	0.5556
p.K497R	DO4677	BRCA	ICGC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation blocking ubiquitination signal	0.5556
p.G432W	TCGA-D3-A2JP	SKCM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation altering degron motif	0.6714
p.G432W	DO47407	SKCM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation altering degron motif	0.6714
p.S423L	TCGA-EK-A2RN	CESC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.1667
p.S423L	DO49958	CESC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.1667
p.L438F	TCGA-ER-A19M	SKCM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.L438F	DO37798	SKCM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.2222
p.K440R	SIDM00327	Hodgkin's Lymphoma	GDSC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation substituting flanking lysine	0.2778
p.K440R	ACH-000754	Lymphoma	CCLE	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation substituting flanking lysine	0.2778
p.K440R	L-428	haematopoietic and lymphoid tissue	COSMIC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation substituting flanking lysine	0.2778
p.C503S	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.2778
p.C503S	ACH-000781	Lung Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.2778
p.C503S	NCI-H2023	lung	COSMIC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.2778
p.G439R	SIDM00794	Other Solid Cancers	GDSC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.1944
p.G439R	ACH-001442	Skin Cancer	CCLE	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.1944
p.G439R	A388	skin	COSMIC	DSGGIS	DEG_SCF_TRCP1_1	429:434	Mutation rewiring degron network	0.1944
p.C503G	SIDM01588	Endometrial Carcinoma	GDSC	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.2778
p.C503G	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENI	DEG_APCC_KENBOX_2	505:509	Mutation rewiring degron network	0.2778

Kaplan plot for MASTL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MASTL

UniProt ID: Q96GX5

Entrez ID: 84930

Protein name: Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MASTL in