DegronMD

Uniprot ID: Q96GX5

Source protein: Serine/threonine-protein kinase greatwall

Source gene: MASTL

Class: DEG_SCF_TRCP1_1

Location: 429:434

E3 ligase: BTRC

DEGRON score: 0.9476

ASA_SCORE: 65.1333

COIL: 0.8665

CONS_SCORE: 0.2791

DSS_SCORE: 0.4463

HELIX: 0.0685

FCONS_SCORE: 0.8387

RIG_SCORE: 0.6699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L438I	TCGA-06-A6S1	GBM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.L438I	DO50113	GBM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.G432E	TCGA-AA-3662	COAD	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.6087
p.G432E	DO8336	COAD	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.6087
p.Q425R	TCGA-AJ-A3EK	UCEC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.Q425R	DO41584	UCEC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.A427D	TCGA-AJ-A3EK	UCEC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.2778
p.A427D	DO41584	UCEC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.2778
p.G432W	TCGA-D3-A2JP	SKCM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.6714
p.G432W	DO47407	SKCM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.6714
p.S423L	TCGA-EK-A2RN	CESC	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.1667
p.S423L	DO49958	CESC	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.1667
p.L438F	TCGA-ER-A19M	SKCM	TCGA	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.L438F	DO37798	SKCM	ICGC	DSGGIS	DEG_SCF_TRCP1_1	0.2222
p.K440R	SIDM00327	Hodgkin's Lymphoma	GDSC	DSGGIS	DEG_SCF_TRCP1_1	0.2778
p.K440R	ACH-000754	Lymphoma	CCLE	DSGGIS	DEG_SCF_TRCP1_1	0.2778
p.K440R	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGIS	DEG_SCF_TRCP1_1	0.2778
p.G439R	SIDM00794	Other Solid Cancers	GDSC	DSGGIS	DEG_SCF_TRCP1_1	0.1944
p.G439R	ACH-001442	Skin Cancer	CCLE	DSGGIS	DEG_SCF_TRCP1_1	0.1944
p.G439R	A388	skin	COSMIC	DSGGIS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GX5	Serine/threonine-protein kinase greatwall	DEG_SCF_TRCP1_1	429:434	DSGGIS	BTRC	0.9476	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons