DegronMD

Uniprot ID: P42684

Source protein: Tyrosine-protein kinase ABL2

Source gene: ABL2

Class: DEG_SCF_FBW7_1

Location: 162:167

E3 ligase: FBXW7

DEGRON score: 0.6942

ASA_SCORE: 55.65

COIL: 0.673

CONS_SCORE: 0.7556

DSS_SCORE: 0.2373

HELIX: 0.0733

FCONS_SCORE: 0.9982

RIG_SCORE: 0.7746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T163N	TCGA-44-5644	LUAD	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.8166
p.S167N	TCGA-A6-6780	COAD	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.7069
p.L168Q	TCGA-AJ-A3BG	UCEC	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.3056
p.P164S	TCGA-DU-6407	LGG	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.6752
p.S159N	TCGA-E7-A7DU	BLCA	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.6944
p.S159N	SIDM00960	Colorectal Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.6944
p.S159N	ACH-000798	Colon/Colorectal Cancer	CCLE	ITPVNS	DEG_SCF_FBW7_1	0.6944
p.S159N	CL-40	large_intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.6944
p.S174L	DO48368	BLCA	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.5833
p.S172P	DO233885	GACA	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.1944
p.G169W	DO44458	KIRC	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.2778
p.P168T	DO228952	LICA	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.3056
p.S166N	DO36556	READ	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.7069
p.R176M	DO227677	SKCA	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.0833
p.P168L	DO37819	SKCM	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.3056
p.P168S	DO37819	SKCM	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.3056
p.A168T	CW-2	large_intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.3056
p.A162T	CW-2	large_intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons