DegronMD

Uniprot ID: P00519

Source protein: Tyrosine-protein kinase ABL1

Source gene: ABL1

Class: DEG_SCF_FBW7_1

Location: 116:121

E3 ligase: FBXW7

DEGRON score: 0.8242

ASA_SCORE: 47.9167

COIL: 0.7273

CONS_SCORE: 0.7741

DSS_SCORE: 0.2519

HELIX: 0.0427

FCONS_SCORE: 0.9999

RIG_SCORE: 0.7869

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K106N	TCGA-09-2051	OV	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.T123I	TCGA-DY-A0XA	READ	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.2778
p.V130L	TCGA-EV-5903	KIRP	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.0833
p.G116W	TCGA-FI-A2F4	UCEC	TCGA	ITPVNS	DEG_SCF_FBW7_1	0.7825
p.V111L	DO20890	KIRP	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.1944
p.V119F	DO228976	LICA	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.5957
p.P131S	DO46657	PAAD	ICGC	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.P131S	SIDM00482	Chronic Myelogenous Leukemia	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.P131S	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.K106E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.K106E	KYSE-410	oesophagus	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.0556
p.N115S	SIDM00394	Cervical Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.N115S	SIDM00488	Colorectal Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.N115S	SIDM01551	Gastric Carcinoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.N115S	SIDM01494	Glioblastoma	GDSC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.N115S	SISO	cervix	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.N115S	CaR-1	large_intestine	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.75
p.P112S	ACH-002302	Leukemia	CCLE	ITPVNS	DEG_SCF_FBW7_1	0.2222
p.P112S	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.2222
p.C119G	MDA-MB-436	breast	COSMIC	ITPVNS	DEG_SCF_FBW7_1	0.76

Drug responses associated with ABL1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000809	Esophageal Cancer	p.K87E (No)	CCLE	Nilotinib	5.1288
ACH-000809	Esophageal Cancer	p.K87E (No)	CCLE	AZD0530	8
ACH-000445	Brain Cancer	p.N96S (No)	CCLE	Nilotinib	8
ACH-000445	Brain Cancer	p.N96S (No)	CCLE	AZD0530	8
ACH-000573	Breast Cancer	p.C100G (No)	CCLE	Nilotinib	8
ACH-000573	Breast Cancer	p.C100G (No)	CCLE	AZD0530	8
ACH-000994	Endometrial/Uterine Cancer	p.S164L (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.S164L (No)	CCLE	AZD0530	8
ACH-000973	Bladder Cancer	p.Y215H (No)	CCLE	Nilotinib	8
ACH-000973	Bladder Cancer	p.Y215H (No)	CCLE	AZD0530	8
ACH-000971	Colon/Colorectal Cancer	p.Y257C (No)	CCLE	Nilotinib	8
ACH-000971	Colon/Colorectal Cancer	p.Y257C (No)	CCLE	AZD0530	8
ACH-000588	Myeloma	p.E275K (No)	CCLE	Nilotinib	6.0013
ACH-000588	Myeloma	p.E275K (No)	CCLE	AZD0530	8
ACH-000994	Endometrial/Uterine Cancer	p.M290V (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.M290V (No)	CCLE	AZD0530	8
ACH-000434	Lung Cancer	p.R332W (No)	CCLE	Nilotinib	8
ACH-000434	Lung Cancer	p.R332W (No)	CCLE	AZD0530	8
ACH-000832	Head and Neck Cancer	p.P441L (No)	CCLE	AZD0530	1.1805
ACH-000994	Endometrial/Uterine Cancer	p.W476* (No)	CCLE	Nilotinib	8
ACH-000994	Endometrial/Uterine Cancer	p.W476* (No)	CCLE	AZD0530	8
ACH-000843	Lung Cancer	p.E527K (No)	CCLE	AZD0530	8
ACH-000914	Lymphoma	p.H552R (No)	CCLE	Nilotinib	8
ACH-000914	Lymphoma	p.H552R (No)	CCLE	AZD0530	8
ACH-000646	Ovarian Cancer	p.R639Q (No)	CCLE	Nilotinib	8
ACH-000646	Ovarian Cancer	p.R639Q (No)	CCLE	AZD0530	3.4851
ACH-000919	Gastric Cancer	p.P662L (No)	CCLE	Nilotinib	8
ACH-000919	Gastric Cancer	p.P662L (No)	CCLE	AZD0530	8
ACH-000753	Bladder Cancer	p.P669S (No)	CCLE	Nilotinib	5.0116
ACH-000753	Bladder Cancer	p.P669S (No)	CCLE	AZD0530	8
ACH-000943	Colon/Colorectal Cancer	p.F747I (No)	CCLE	Nilotinib	8
ACH-000943	Colon/Colorectal Cancer	p.F747I (No)	CCLE	AZD0530	8
ACH-000756	Brain Cancer	p.G753V (No)	CCLE	AZD0530	8
ACH-000984	Endometrial/Uterine Cancer	p.P782S (No)	CCLE	Nilotinib	2.0399
ACH-000984	Endometrial/Uterine Cancer	p.P782S (No)	CCLE	AZD0530	8
ACH-000966	Ovarian Cancer	p.P784fs (No)	CCLE	Nilotinib	8
ACH-000966	Ovarian Cancer	p.P784fs (No)	CCLE	AZD0530	0.7612
ACH-000983	Leukemia	p.E791G (No)	CCLE	Nilotinib	0.0137
ACH-000983	Leukemia	p.E791G (No)	CCLE	AZD0530	0.5514
ACH-000851	Lung Cancer	p.T814A (No)	CCLE	AZD0530	8
ACH-000988	Endometrial/Uterine Cancer	p.A825V (No)	CCLE	AZD0530	0.0217
ACH-000445	Brain Cancer	p.R876G (No)	CCLE	Nilotinib	8
ACH-000445	Brain Cancer	p.R876G (No)	CCLE	AZD0530	8
ACH-000961	Endometrial/Uterine Cancer	p.P900S (No)	CCLE	AZD0530	8
ACH-000963	Colon/Colorectal Cancer	p.P900S (No)	CCLE	AZD0530	0.6765
ACH-000963	Colon/Colorectal Cancer	p.A922V (No)	CCLE	AZD0530	0.6765
ACH-000579	Skin Cancer	p.P951S (No)	CCLE	AZD0530	8
ACH-000579	Skin Cancer	p.P951L (No)	CCLE	AZD0530	8
ACH-000946	Endometrial/Uterine Cancer	p.S1024N (No)	CCLE	Nilotinib	8
ACH-000946	Endometrial/Uterine Cancer	p.S1024N (No)	CCLE	AZD0530	8
ACH-000580	Skin Cancer	p.A1026T (No)	CCLE	Nilotinib	8
ACH-000580	Skin Cancer	p.A1026T (No)	CCLE	AZD0530	8
ACH-000946	Endometrial/Uterine Cancer	p.N1046S (No)	CCLE	Nilotinib	8
ACH-000946	Endometrial/Uterine Cancer	p.N1046S (No)	CCLE	AZD0530	8
ACH-000107	Pancreatic Cancer	p.G1060D (No)	CCLE	Nilotinib	0.0629
ACH-000107	Pancreatic Cancer	p.G1060D (No)	CCLE	AZD0530	1.1036
ACH-000190	Lymphoma	p.I1127T (No)	CCLE	AZD0530	8
ACH-000790	Lung Cancer	p.V1128E (No)	CCLE	Nilotinib	8
ACH-000790	Lung Cancer	p.V1128E (No)	CCLE	AZD0530	8
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Ponatinib	7.5816
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Nilotinib	29.355
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Bosutinib	8.2362
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Nilotinib	8.5463
SIDM00213	THCA\|thyroid	p.P829L (No)	GDSC	Dasatinib	11.504
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Imatinib	34.0987
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Saracatinib	32.7652
SIDM00189	SKCM\|melanoma	p.G1044D (No)	GDSC	Dasatinib	0.252
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Imatinib	21.4341
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Saracatinib	13.7046
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Dasatinib	3.1241
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Ponatinib	5.2697
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Nilotinib	5.6016
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Bosutinib	1.5956
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Nilotinib	605.57
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.I1146T (No)	GDSC	Dasatinib	331.1
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Imatinib	0.1788
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Saracatinib	0.4925
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Dasatinib	0.0017
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Ponatinib	0.0014
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Nilotinib	0.0168
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Bosutinib	1.3084
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Nilotinib	0.0198
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.E810G (No)	GDSC	Dasatinib	0.001
SIDM00629	BRCA\|breast	p.C119G (Yes)	GDSC	Ponatinib	13.8061
SIDM00629	BRCA\|breast	p.C119G (Yes)	GDSC	Nilotinib	56.4933
SIDM00629	BRCA\|breast	p.C119G (Yes)	GDSC	Bosutinib	12.2232
SIDM00629	BRCA\|breast	p.C119G (Yes)	GDSC	Nilotinib	38.49
SIDM00629	BRCA\|breast	p.C119G (Yes)	GDSC	Dasatinib	80.481
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Imatinib	22.6084
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Saracatinib	22.6084
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Dasatinib	7.4817
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Ponatinib	5.3173
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Nilotinib	17.9504
SIDM00661	DLBC\|B_cell_lymphoma	p.H571R (No)	GDSC	Bosutinib	18.5762
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Imatinib	7.6142
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Saracatinib	34.6491
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Dasatinib	21.2398
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Ponatinib	3.947
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Nilotinib	16.6512
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Bosutinib	27.1251
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Nilotinib	5.1124
SIDM00683	PRAD\|prostate	p.N789S (No)	GDSC	Dasatinib	11.862
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Imatinib	27.0124
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Saracatinib	22.0925
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Dasatinib	4.7849
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Ponatinib	6.2969
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Nilotinib	26.5156
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Bosutinib	25.7167
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Nilotinib	44.509
SIDM00108	SKCM\|melanoma	p.P970S (No)	GDSC	Dasatinib	24.321
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Imatinib	27.0124
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Saracatinib	22.0925
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Dasatinib	4.7849
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Ponatinib	6.2969
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Nilotinib	26.5156
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Bosutinib	25.7167
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Nilotinib	44.509
SIDM00108	SKCM\|melanoma	p.P970L (No)	GDSC	Dasatinib	24.321
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Ponatinib	5.7252
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Nilotinib	9.5153
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Bosutinib	0.7821
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Nilotinib	63.863
SIDM00937	HNSC\|head_and_neck	p.P460L (No)	GDSC	Dasatinib	0.6476
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Imatinib	30.0665
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Saracatinib	3.8183
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Dasatinib	0.0758
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Ponatinib	0.2064
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Nilotinib	11.5883
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Bosutinib	30.4323
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Nilotinib	139.61
SIDM00224	MESO\|mesothelioma	p.P829L (No)	GDSC	Dasatinib	0.4822
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Imatinib	7.0465
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Saracatinib	6.9327
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Dasatinib	9.295
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Ponatinib	3.0818
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Nilotinib	19.2011
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Bosutinib	17.5855
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Nilotinib	5.5348
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.V1147E (No)	GDSC	Dasatinib	28.96
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Ponatinib	0.3787
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Nilotinib	38.3601
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Bosutinib	14.6104
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Nilotinib	96.439
SIDM00669	PAAD\|pancreas	p.P829L (No)	GDSC	Dasatinib	8.1022
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Ponatinib	3.3793
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Nilotinib	12.459
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Bosutinib	2.7762
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Nilotinib	72.987
SIDM00664	PAAD\|pancreas	p.R608H (No)	GDSC	Dasatinib	5.2866
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Ponatinib	7.182
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Nilotinib	76.8649
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Bosutinib	26.491
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Nilotinib	24.774
SIDM00381	CESC\|cervix	p.A846S (No)	GDSC	Dasatinib	0.7739
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Ponatinib	3.0724
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Nilotinib	7.1112
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Bosutinib	2.8089
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Nilotinib	4.4213
SIDM00591	HNSC\|head_and_neck	p.R153C (No)	GDSC	Dasatinib	0.3335
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Nilotinib	14.7574
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Bosutinib	1.1488
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Nilotinib	22.995
SIDM00393	STAD\|stomach	p.T243I (No)	GDSC	Dasatinib	0.5865
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Ponatinib	5.2959
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Nilotinib	54.6566
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Bosutinib	55.356
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Nilotinib	417.69
SIDM00943	PAAD\|pancreas	p.G1079D (No)	GDSC	Dasatinib	0.2994
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Ponatinib	5.6088
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Nilotinib	9.9916
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Bosutinib	8.9003
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Nilotinib	42.713
SIDM00251	STAD\|stomach	p.G720S (No)	GDSC	Dasatinib	24.196
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Ponatinib	5.6088
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Nilotinib	9.9916
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Bosutinib	8.9003
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Nilotinib	42.713
SIDM00251	STAD\|stomach	p.E890K (No)	GDSC	Dasatinib	24.196
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Imatinib	19.0757
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Saracatinib	13.6546
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Dasatinib	0.398
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Ponatinib	1.11
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Nilotinib	5.0496
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Bosutinib	11.2427
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Nilotinib	5.9646
SIDM01090	COREAD\|large_intestine	p.F766I (No)	GDSC	Dasatinib	6.118
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Imatinib	17.9874
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Saracatinib	28.8907
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Dasatinib	0.296
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Ponatinib	2.323
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Nilotinib	12.9886
SIDM00516	SKCM\|melanoma	p.R185K (No)	GDSC	Bosutinib	23.3431
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Imatinib	21.8954
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Saracatinib	10.9873
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Dasatinib	2.9394
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Ponatinib	0.1275
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Nilotinib	28.4004
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Bosutinib	11.8456
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Nilotinib	12.353
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.V587M (No)	GDSC	Dasatinib	0.9106
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Nilotinib	53.508
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Bosutinib	0.5623
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Nilotinib	77.517
SIDM00151	OV\|ovary	p.R804fs*3 (No)	GDSC	Dasatinib	0.0537
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Imatinib	20.3906
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Saracatinib	23.7883
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Dasatinib	2.1819
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Ponatinib	4.7966
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Nilotinib	3.6021
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Bosutinib	0.5976
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.P131S (Yes)	GDSC	Dasatinib	0.8259
SIDM00488	COREAD\|large_intestine	p.N115S (Yes)	GDSC	Ponatinib	15.2626
SIDM00488	COREAD\|large_intestine	p.N115S (Yes)	GDSC	Nilotinib	37.456
SIDM00488	COREAD\|large_intestine	p.N115S (Yes)	GDSC	Bosutinib	6.7991
SIDM00488	COREAD\|large_intestine	p.N115S (Yes)	GDSC	Nilotinib	95.088
SIDM00488	COREAD\|large_intestine	p.N115S (Yes)	GDSC	Dasatinib	0.36
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Ponatinib	15.2626
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Nilotinib	37.456
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Bosutinib	6.7991
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Nilotinib	95.088
SIDM00488	COREAD\|large_intestine	p.R895G (No)	GDSC	Dasatinib	0.36
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Ponatinib	1.0217
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Nilotinib	12.5319
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Bosutinib	11.5105
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Nilotinib	74.547
SIDM00602	STAD\|stomach	p.P681L (No)	GDSC	Dasatinib	64.078
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Imatinib	30.9572
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Saracatinib	29.8267
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Dasatinib	19.5207
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Ponatinib	0.5561
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Nilotinib	29.6826
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Bosutinib	10.0095
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Nilotinib	122.33
SIDM00577	NB\|neuroblastoma	p.A666D (No)	GDSC	Dasatinib	90.238
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Ponatinib	1.7574
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Nilotinib	31.0453
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Bosutinib	28.0105
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Nilotinib	13.516
SIDM00258	NB\|neuroblastoma	p.K915N (No)	GDSC	Dasatinib	26.961
SIDM01028	ESCA\|oesophagus	p.K106E (Yes)	GDSC	Ponatinib	0.5687
SIDM01028	ESCA\|oesophagus	p.K106E (Yes)	GDSC	Nilotinib	29.8309
SIDM01028	ESCA\|oesophagus	p.K106E (Yes)	GDSC	Bosutinib	1.5131
SIDM01028	ESCA\|oesophagus	p.K106E (Yes)	GDSC	Nilotinib	230.24
SIDM01028	ESCA\|oesophagus	p.K106E (Yes)	GDSC	Dasatinib	2.2175
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Imatinib	30.3559
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Saracatinib	6.711
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Dasatinib	1.1025
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Ponatinib	0.5733
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Nilotinib	12.664
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Bosutinib	3.6028
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Nilotinib	46.883
SIDM01092	STAD\|stomach	p.R649H (No)	GDSC	Dasatinib	3.4925
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Ponatinib	1.1816
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Nilotinib	16.8693
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Bosutinib	9.7868
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Nilotinib	66.66
SIDM00333	UCEC\|endometrium	p.P829L (No)	GDSC	Dasatinib	12.799
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Ponatinib	1.1816
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Nilotinib	16.8693
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Bosutinib	9.7868
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Nilotinib	66.66
SIDM00333	UCEC\|endometrium	p.A844V (No)	GDSC	Dasatinib	12.799
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (No)	GDSC	Ponatinib	1.7349
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (No)	GDSC	Nilotinib	6.352
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (No)	GDSC	Bosutinib	0.8214
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (No)	GDSC	Nilotinib	9.0412
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E546K (No)	GDSC	Dasatinib	1.3473
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Imatinib	14.3579
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Saracatinib	10.6651
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Dasatinib	12.2387
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Ponatinib	3.2515
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Nilotinib	10.612
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Bosutinib	7.7999
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Nilotinib	6.1217
SIDM00256	NB\|neuroblastoma	p.P829L (No)	GDSC	Dasatinib	18.539
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Ponatinib	3.6123
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Nilotinib	14.9169
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Bosutinib	24.8986
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Nilotinib	100.34
SIDM01199	LIHC\|liver	p.H415Q (No)	GDSC	Dasatinib	0.8905
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Ponatinib	5.6195
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Nilotinib	36.9507
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Bosutinib	6.3453
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Nilotinib	67.004
SIDM00140	SKCM\|melanoma	p.T719I (No)	GDSC	Dasatinib	54.529
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Imatinib	28.2456
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Saracatinib	28.2456
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Dasatinib	2.339
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Ponatinib	7.2309
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Nilotinib	21.6398
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Bosutinib	4.1634
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Nilotinib	17.611
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A156T (No)	GDSC	Dasatinib	2.7968
SIDM00216	COREAD\|large_intestine	p.R839W (No)	GDSC	Nilotinib	39.635
SIDM00216	COREAD\|large_intestine	p.R839W (No)	GDSC	Dasatinib	11.384
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Ponatinib	0.4167
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Nilotinib	12.7375
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Bosutinib	7.2686
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Nilotinib	44.488
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P829L (No)	GDSC	Dasatinib	36.084
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Ponatinib	1.0474
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Nilotinib	4.4301
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Bosutinib	6.3239
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Nilotinib	100.63
SIDM00596	UCEC\|endometrium	p.R502W (No)	GDSC	Dasatinib	24.115
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Imatinib	17.1814
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Saracatinib	7.1883
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Dasatinib	2.8208
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Ponatinib	5.3797
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Nilotinib	27.2806
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Bosutinib	18.6769
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Nilotinib	13.479
SIDM00888	MB\|medulloblastoma	p.A988T (No)	GDSC	Dasatinib	4.1606
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Ponatinib	3.4514
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Nilotinib	27.0036
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Bosutinib	28.6195
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Nilotinib	36.126
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R351W (No)	GDSC	Dasatinib	6.1436
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Ponatinib	0.2316
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Nilotinib	5.6714
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Bosutinib	1.5957
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Nilotinib	8.5519
SIDM00783	COREAD\|large_intestine	p.Y276C (No)	GDSC	Dasatinib	20.176
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Ponatinib	2.7183
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Nilotinib	15.1943
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340W (No)	GDSC	Bosutinib	4.6417
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Ponatinib	2.7183
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Nilotinib	15.1943
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G340V (No)	GDSC	Bosutinib	4.6417
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Imatinib	9.4971
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Saracatinib	7.0934
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Dasatinib	3.5196
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Ponatinib	0.6636
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Nilotinib	5.0462
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Bosutinib	1.2306
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Nilotinib	16.572
SIDM00329	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q1131L (No)	GDSC	Dasatinib	7.4495
SIDM00819	KIRC\|kidney	p.V741I (No)	GDSC	Nilotinib	26.2977
SIDM00819	KIRC\|kidney	p.V741I (No)	GDSC	Bosutinib	2.5975
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Ponatinib	1.3941
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Nilotinib	6.6727
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Bosutinib	0.9409
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Nilotinib	15.032
SIDM00589	HNSC\|head_and_neck	p.V390I (No)	GDSC	Dasatinib	0.35
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Imatinib	11.7665
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Saracatinib	9.4351
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Dasatinib	0.3358
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Ponatinib	17.9617
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Nilotinib	84.1662
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Bosutinib	84.1662
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Nilotinib	393.51
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P845S (No)	GDSC	Dasatinib	13.657
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Ponatinib	2.9188
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Nilotinib	43.2506
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Bosutinib	32.6575
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Nilotinib	38.395
SIDM00680	COREAD\|large_intestine	p.G883fs*12 (No)	GDSC	Dasatinib	91.676
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Imatinib	18.1693
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Saracatinib	1.4536
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Dasatinib	0.629
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Ponatinib	1.2325
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Nilotinib	5.3117
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Bosutinib	17.0982
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Nilotinib	5.5543
SIDM00273	LGG\|glioma	p.G772V (No)	GDSC	Dasatinib	1.8506
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Ponatinib	4.8982
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Nilotinib	28.1913
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Bosutinib	2.5364
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Nilotinib	50.77
SIDM00487	COREAD\|large_intestine	p.P919S (No)	GDSC	Dasatinib	2.8765
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Ponatinib	4.8982
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Nilotinib	28.1913
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Bosutinib	2.5364
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Nilotinib	50.77
SIDM00487	COREAD\|large_intestine	p.A941V (No)	GDSC	Dasatinib	2.8765
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Imatinib	51.6867
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Saracatinib	55.2762
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Dasatinib	34.4884
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Ponatinib	13.9216
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Nilotinib	42.4131
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Bosutinib	58.7424
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Nilotinib	5.7947
SIDM00282	COREAD\|large_intestine	p.K527fs*12 (No)	GDSC	Dasatinib	11.536
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Ponatinib	3.0934
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Nilotinib	8.1334
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Bosutinib	5.0631
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Nilotinib	28.375
SIDM00414	BLCA\|bladder	p.P933L (No)	GDSC	Dasatinib	6.2651
SIDM00394	CESC\|cervix	p.N115S (Yes)	GDSC	Ponatinib	5.6886
SIDM00394	CESC\|cervix	p.N115S (Yes)	GDSC	Nilotinib	22.2542
SIDM00394	CESC\|cervix	p.N115S (Yes)	GDSC	Bosutinib	4.8195
SIDM00394	CESC\|cervix	p.N115S (Yes)	GDSC	Nilotinib	134.56
SIDM00394	CESC\|cervix	p.N115S (Yes)	GDSC	Dasatinib	86.642
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Ponatinib	10.6712
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Nilotinib	10.8952
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Bosutinib	20.6924
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Nilotinib	79.804
SIDM00890	SKCM\|melanoma	p.A1045T (No)	GDSC	Dasatinib	65.834
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Ponatinib	1.7558
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Nilotinib	26.4867
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Bosutinib	15.9857
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Nilotinib	3.0704
SIDM00135	BRCA\|breast	p.K7R (No)	GDSC	Dasatinib	0.0885
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Ponatinib	1.9526
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Nilotinib	5.2668
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Bosutinib	2.5114
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Nilotinib	23.11
SIDM00537	COREAD\|large_intestine	p.N617D (No)	GDSC	Dasatinib	9.6455
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Ponatinib	1.9526
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Nilotinib	5.2668
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Bosutinib	2.5114
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Nilotinib	23.11
SIDM00537	COREAD\|large_intestine	p.A964V (No)	GDSC	Dasatinib	9.6455
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Imatinib	26.8732
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Saracatinib	25.3576
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Dasatinib	1.0835
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Ponatinib	0.6336
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Nilotinib	15.4703
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Bosutinib	10.0496
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Nilotinib	20.431
SIDM00374	DLBC\|B_cell_lymphoma	p.S1063C (No)	GDSC	Dasatinib	1.8875
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Imatinib	9.2701
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Saracatinib	12.7268
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Dasatinib	10.8097
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Ponatinib	0.1843
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Nilotinib	2.4803
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Bosutinib	21.8578
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Nilotinib	22.911
SIDM00410	ALL\|lymphoid_neoplasm_other	p.K908E (No)	GDSC	Dasatinib	3.503
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Ponatinib	8.7607
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Nilotinib	13.2045
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Bosutinib	25.4631
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Nilotinib	10.756
SIDM00920	BRCA\|breast	p.P829L (No)	GDSC	Dasatinib	19.827
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Imatinib	27.7885
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Saracatinib	14.093
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Dasatinib	1.9569
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Ponatinib	1.2656
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Nilotinib	28.7699
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Bosutinib	6.4408
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Nilotinib	30.219
SIDM00796	UNCLASSIFIED\|head_and_neck	p.R608H (No)	GDSC	Dasatinib	4.6012

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00519	Tyrosine-protein kinase ABL1	DEG_SCF_FBW7_1	116:121	ITPVNS	FBXW7	0.8242	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SCF_FBW7_1	162:167	ITPVNS	FBXW7	0.6942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPVNS

Degron related mutations and impact score

Drug responses associated with ABL1 mutations

All proteins holding degron of ITPVNS