DegronMD

Uniprot ID: Q5VWT5

Source protein: FYN-binding protein 2

Source gene: FYB2

Class: DEG_APCC_KENBOX_2

Location: 563:567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8283

ASA_SCORE: 98.06

COIL: 0.693

CONS_SCORE: 0.7107

DSS_SCORE: 0.1648

HELIX: 0.2746

FCONS_SCORE: 1.1898

RIG_SCORE: 0.7649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D576V	SIDM00367	Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.0833
p.D576V	SBC-3	lung	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.0833
p.S563L	SIDM01161	Other Sarcomas	GDSC	SKENL	DEG_APCC_KENBOX_2	0.6556
p.S563L	SW982	soft_tissue	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.6556
p.S571C	SIDM01033	Bladder Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.S571C	KU-19-19	urinary_tract	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.S571A	SIDM01033	Bladder Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.S571A	KU-19-19	urinary_tract	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.P575S	SIDM01609	Endometrial Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons