DegronMD

Uniprot ID: O43526

Source protein: Potassium voltage-gated channel subfamily KQT member 2

Source gene: KCNQ2

Class: DEG_APCC_KENBOX_2

Location: 810:814

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9043

ASA_SCORE: 80.14

COIL: 0.5256

CONS_SCORE: 0.3208

DSS_SCORE: 0.2028

HELIX: 0.406

FCONS_SCORE: 1.2298

RIG_SCORE: 0.7454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S808Y	TCGA-63-7021	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.2778
p.S808Y	TCGA-78-7155	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.2778
p.N813K	TCGA-66-2763	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.6918
p.F805L	TCGA-AZ-6607	COAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.1944
p.I807V	TCGA-BR-6452	STAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.25
p.S821P	DO222973	BTCA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.5833
p.A817V	DO230315	COCA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.25
p.A817V	DO232761	PBCA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.25
p.I816T	DO16570	KIRC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.2778
p.G819E	DO222434	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.G819R	DO222837	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	0.1944
p.R813M	DO37543	SKCM	ICGC	SKENL	DEG_APCC_KENBOX_2	0.8632
p.Y821C	SIDM01045	Endometrial Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.5833
p.Y821C	EN	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.5833
p.S803R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.1389
p.S803R	ACH-000900	Lung Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	0.1389
p.F802V	SIDM00784	Glioma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.1111
p.Y803C	EN	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons