DegronMD - Q5VWT5(FYB2)

FYB2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D576V	SIDM00367	Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.0833
p.D576V	SIDM00367	Small Cell Lung Carcinoma	GDSC	VIIYDD	LIG_APCC_ABBA_1	584:589	Mutation rewiring degron network	0.1111
p.D576V	SBC-3	lung	COSMIC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.0833
p.D576V	SBC-3	lung	COSMIC	VIIYDD	LIG_APCC_ABBA_1	584:589	Mutation rewiring degron network	0.1111
p.S563L	SIDM01161	Other Sarcomas	GDSC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation altering degron motif	0.6556
p.S563L	SW982	soft tissue	COSMIC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation altering degron motif	0.6556
p.S571C	SIDM01033	Bladder Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2222
p.S571C	KU-19-19	urinary tract	COSMIC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2222
p.S571A	SIDM01033	Bladder Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2222
p.S571A	KU-19-19	urinary tract	COSMIC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.2222
p.P575S	SIDM01609	Endometrial Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	563:567	Mutation rewiring degron network	0.1111
p.P575S	SIDM01609	Endometrial Carcinoma	GDSC	VIIYDD	LIG_APCC_ABBA_1	584:589	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc