DegronMD

Uniprot ID: Q5VWT5

Source protein: FYN-binding protein 2

Source gene: FYB2

Class: LIG_APCC_ABBA_1

Location: 584:589

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9449

ASA_SCORE: 74.6333

COIL: 0.5073

CONS_SCORE: 0.7046

DSS_SCORE: 0.2068

HELIX: 0.0935

FCONS_SCORE: 1.2172

RIG_SCORE: 0.8815

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D576V	SIDM00367	Small Cell Lung Carcinoma	GDSC	VIIYDD	LIG_APCC_ABBA_1	0.1111
p.D576V	SBC-3	lung	COSMIC	VIIYDD	LIG_APCC_ABBA_1	0.1111
p.P575S	SIDM01609	Endometrial Carcinoma	GDSC	VIIYDD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWT5	FYN-binding protein 2	LIG_APCC_ABBA_1	584:589	VIIYDD	APC,CDC20,FZR1	0.9449	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons