DegronMD

Uniprot ID: P30414

Source protein: NK-tumor recognition protein

Source gene: NKTR

Class: DEG_APCC_KENBOX_2

Location: 981:985

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7579

ASA_SCORE: 116.58

COIL: 0.8052

CONS_SCORE: 0.2893

DSS_SCORE: 0.8549

HELIX: 0.186

FCONS_SCORE: 0.9065

RIG_SCORE: 0.574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E995D	TCGA-A5-A2K5	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.0556
p.E995D	DO231040	LUSC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0556
p.E995D	DO41379	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.0556
p.K982E	TCGA-EY-A1GI	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.7022
p.K982E	DO41211	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.7022
p.R973W	NCI-H630	large_intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.R973W	HT-115	large_intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.2222
p.R986C	SNG-M	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons