DegronMD - P30414(NKTR)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1237S	TCGA-67-3771	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.25
p.A1237S	DO25797	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.25
p.A1236S	TCGA-99-8028	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.2222
p.A1236S	DO23561	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.2222
p.E995D	TCGA-A5-A2K5	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation rewiring degron network	0.0556
p.E995D	DO231040	LUSC	ICGC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation rewiring degron network	0.0556
p.E995D	DO41379	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation rewiring degron network	0.0556
p.T1125K	TCGA-AG-4021	READ	TCGA	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.1667
p.T1125K	DO36605	READ	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.1667
p.L1123I	TCGA-AX-A2HC	UCEC	TCGA	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.1111
p.L1123I	DO41572	UCEC	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.1111
p.G1233E	TCGA-DU-6392	LGG	TCGA	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.1389
p.G1233E	DO22237	LGG	ICGC	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.1389
p.K982E	TCGA-EY-A1GI	UCEC	TCGA	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation altering degron motif	0.7022
p.K982E	DO41211	UCEC	ICGC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation altering degron motif	0.7022
p.D1135H	TCGA-FD-A3SO	BLCA	TCGA	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation altering degron motif	0.6577
p.D1135H	DO569	BLCA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation altering degron motif	0.6577
p.V1122L	DO228430	BRCA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.0833
p.C1132F	DO229041	LICA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation altering degron motif	0.5996
p.SP1146SS	DO222875	MELA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation blocking phosphorylation signal	0.4444
p.N1234K	ACH-002471	Primary	CCLE	AATSS	DEG_SPOP_SBC_1	1240:1244	Mutation rewiring degron network	0.1667
p.R973W	NCI-H630	large intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation substituting flanking lysine	0.2222
p.R973W	HT-115	large intestine	COSMIC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation substituting flanking lysine	0.2222
p.S1138F	NCI-H2023	lung	COSMIC	ICTPDRS	DEG_SCF_FBW7_1	1131:1137	Mutation rewiring degron network	0.3056
p.R986C	SNG-M	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	981:985	Mutation rewiring degron network	0.3056

Kaplan plot for NKTR in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKTR

UniProt ID: P30414

Entrez ID: 4820

Protein name: NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NKTR in