DegronMD

Uniprot ID: P30414

Source protein: NK-tumor recognition protein

Source gene: NKTR

Class: DEG_SCF_FBW7_1

Location: 1131:1137

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 87.6571

COIL: 0.8969

CONS_SCORE: 0.3447

DSS_SCORE: 0.6447

HELIX: 0.061

FCONS_SCORE: 1.1481

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1125K	TCGA-AG-4021	READ	TCGA	ICTPDRS	DEG_SCF_FBW7_1	0.1667
p.T1125K	DO36605	READ	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.1667
p.L1123I	TCGA-AX-A2HC	UCEC	TCGA	ICTPDRS	DEG_SCF_FBW7_1	0.1111
p.L1123I	DO41572	UCEC	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.1111
p.D1135H	TCGA-FD-A3SO	BLCA	TCGA	ICTPDRS	DEG_SCF_FBW7_1	0.6577
p.D1135H	DO569	BLCA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.6577
p.V1122L	DO228430	BRCA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.0833
p.C1132F	DO229041	LICA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.5996
p.SP1146SS	DO222875	MELA	ICGC	ICTPDRS	DEG_SCF_FBW7_1	0.4444
p.S1138F	NCI-H2023	lung	COSMIC	ICTPDRS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30414	NK-tumor recognition protein	DEG_SCF_FBW7_1	1131:1137	ICTPDRS	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons