DegronMD

Uniprot ID: Q03001

Source protein: Dystonin

Source gene: DST

Class: LIG_APCC_ABBAyCdc20_2

Location: 2422:2428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5575

ASA_SCORE: 84.5

COIL: 0.7453

CONS_SCORE: 0.1903

DSS_SCORE: 0.5692

HELIX: 0.2127

FCONS_SCORE: 0.7546

RIG_SCORE: 0.7374

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2430R	TCGA-17-Z042	LUAD	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E2419G	TCGA-AG-3892	READ	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.K2413T	TCGA-EO-A3AY	UCEC	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K2416N	TCGA-FS-A1ZB	SKCM	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S2431L	TCGA-LL-A73Y	BRCA	TCGA	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.D2432N	DO524	BLCA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D2432N	DO38006	SKCM	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K2414T	DO9002	COAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D2413G	DO7997	COAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P2424T	DO222794	COCA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7031
p.T2421A	DO233919	GACA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N2419Y	DO11100	GBM	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.D2413E	DO228976	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A2435D	DO228986	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T2428K	DO229029	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7306
p.T2423N	DO229022	LICA	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7055
p.Q2433E	DO26423	LUSC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q2421H	DO29830	OV	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L2427P	DO220239	SARC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.R2437W	DO38619	STAD	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E2429K	DO41235	UCEC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L2424F	DO41331	UCEC	ICGC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.6981
p.G2418V	SIDM00806	Osteosarcoma	GDSC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G2418V	HOS	bone	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D2418N	ACH-000855	Esophageal Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D2418N	KYSE-150	oesophagus	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D2418G	ACH-000961	Endometrial/Uterine Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R2422P	ACH-002107	Bone Cancer	CCLE	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7512
p.R2422P	ES6	bone	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7512
p.K2418R	JHOS-4	ovary	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K2418R	MKN1	stomach	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K2418R	OCUB-M	breast	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E2423K	HCT-116	large_intestine	COSMIC	RDCLHPE	LIG_APCC_ABBAyCdc20_2	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RDCLHPE

Degron related mutations and impact score

Drug responses associated with DST mutations

All proteins holding degron of RDCLHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03001	Dystonin	LIG_APCC_ABBAyCdc20_2	2422:2428	RDCLHPE	APC,CDC20,FZR1	0.5575	More...