DegronMD - Q9NZM4(BICRA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T430A	SIDM02039	Colorectal Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.7139
p.P439T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1389
p.P439T	SIDM00694	Other Solid Cancers	GDSC	PATTT	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1389
p.G1225D	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	1226:1230	Mutation rewiring degron network	0.3056
p.G1225D	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	1226:1230	Mutation rewiring degron network	0.3056
p.P912L	SIDM00581	Glioblastoma	GDSC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.1111
p.P912L	GB-1	central nervous system	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.1111
p.A979G	SIDM01045	Endometrial Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.2222
p.A979G	SIDM00580	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.2222
p.A979G	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.2222
p.A979G	EN	endometrium	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.2222
p.G978A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.1944
p.P924L	SIDM01190	Bladder Carcinoma	GDSC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation altering degron motif	0.6471
p.P924L	TCCSUP	urinary tract	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation altering degron motif	0.6471
p.A982S	SIDM00576	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.3056
p.A982S	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.3056
p.D1506G	SIDM00537	Colorectal Carcinoma	GDSC	PGRTPAPS	DEG_SCF_FBW7_1	1515:1522	Mutation rewiring degron network	0.0833
p.D1506G	GP5d	large intestine	COSMIC	PGRTPAPS	DEG_SCF_FBW7_1	1515:1522	Mutation rewiring degron network	0.0833
p.A997V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.0556
p.A997V	SIDM00579	Neuroblastoma	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.0556
p.A997V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.0556
p.A997V	NB(TU)1-10	autonomic ganglia	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.0556
p.A982T	SIDM01612	Endometrial Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation rewiring degron network	0.3056
p.R1220Q	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1226:1230	Mutation rewiring degron network	0.1667
p.T933P	MFE-319	endometrium	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.1111
p.A927G	EN	endometrium	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.2778
p.A927G	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.2778
p.N983S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation altering degron motif	0.7069
p.A930S	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.1944
p.P915L	TOV-21G	ovary	COSMIC	PTPPPT	DEG_SCF_FBW7_1	920:925	Mutation rewiring degron network	0.1944
p.P902S	RKO	large intestine	COSMIC	VASSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0556
p.T985P	MFE-319	endometrium	COSMIC	PQTST	DEG_SPOP_SBC_1	983:987	Mutation altering degron motif	0.7031
p.P872L	TCCSUP	urinary tract	COSMIC	PPSST	DEG_SPOP_SBC_1	880:884	Mutation rewiring degron network	0.1111
p.R889W	HCT-116	large intestine	COSMIC	VASSS	DEG_SPOP_SBC_1	888:892	Mutation altering degron motif	0.8634
p.P885Q	CHL-1	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	880:884	Mutation rewiring degron network	0.3056
p.P885Q	CHL-1	skin	COSMIC	VASSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.25

Kaplan plot for BICRA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICRA

UniProt ID: Q9NZM4

Entrez ID: 29998

Protein name: BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BICRA in