DegronMD

Uniprot ID: Q9NZM4

Source protein: BRD4-interacting chromatin-remodeling complex-associated protein

Source gene: BICRA

Class: DEG_SCF_FBW7_1

Location: 920:925

E3 ligase: FBXW7

DEGRON score: 0.971

ASA_SCORE: 94.6

COIL: 0.9733

CONS_SCORE: 0.4767

DSS_SCORE: 0.7914

HELIX: 0.012

FCONS_SCORE: 0.9583

RIG_SCORE: 0.4883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P912L	SIDM00581	Glioblastoma	GDSC	PTPPPT	DEG_SCF_FBW7_1	0.1111
p.P912L	GB-1	central_nervous_system	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.1111
p.P924L	SIDM01190	Bladder Carcinoma	GDSC	PTPPPT	DEG_SCF_FBW7_1	0.6471
p.P924L	TCCSUP	urinary_tract	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.6471
p.T933P	MFE-319	endometrium	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.1111
p.A927G	EN	endometrium	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.2778
p.A927G	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.2778
p.A930S	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.1944
p.P915L	TOV-21G	ovary	COSMIC	PTPPPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49715	CCAAT/enhancer-binding protein alpha	DEG_SCF_FBW7_1	225:230	PTPPPT	FBXW7	0.9192	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SCF_FBW7_1	920:925	PTPPPT	FBXW7	0.971	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SCF_FBW7_1	478:483	PTPPPT	FBXW7	0.8322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons