DegronMD

Uniprot ID: P49715

Source protein: CCAAT/enhancer-binding protein alpha

Source gene: CEBPA

Class: DEG_SCF_FBW7_1

Location: 225:230

E3 ligase: FBXW7

DEGRON score: 0.9192

ASA_SCORE: 96.0167

COIL: 0.9822

CONS_SCORE: 0.4619

DSS_SCORE: 0.8325

HELIX: 0.0045

FCONS_SCORE: 0.9688

RIG_SCORE: 0.4958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A240V	DO224566	LUSC	ICGC	PTPPPT	DEG_SCF_FBW7_1	0.0556
p.P229H	DO232224	PBCA	ICGC	PTPPPT	DEG_SCF_FBW7_1	0.6583
p.P237T	ACH-001318	Liver Cancer	CCLE	PTPPPT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49715	CCAAT/enhancer-binding protein alpha	DEG_SCF_FBW7_1	225:230	PTPPPT	FBXW7	0.9192	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SCF_FBW7_1	920:925	PTPPPT	FBXW7	0.971	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SCF_FBW7_1	478:483	PTPPPT	FBXW7	0.8322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons