DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTPPPT
Uniprot ID:
D6RIA3
Source protein:
Uncharacterized protein C4orf54
Source gene:
C4orf54
Class:
DEG_SCF_FBW7_1
Location:
478:483
E3 ligase:
FBXW7
DEGRON score:
0.8322
ASA_SCORE:
87.9667
COIL:
0.9795
CONS_SCORE:
0.4015
DSS_SCORE:
0.8792
HELIX:
0.0085
FCONS_SCORE:
0.7293
RIG_SCORE:
0.4564
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with C4orf54 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPPPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49715
CCAAT/enhancer-binding protein alpha
DEG_SCF_FBW7_1
225:230
PTPPPT
FBXW7
0.9192
More...
Q9NZM4
BRD4-interacting chromatin-remodeling complex-associated protein
DEG_SCF_FBW7_1
920:925
PTPPPT
FBXW7
0.971
More...
D6RIA3
Uncharacterized protein C4orf54
DEG_SCF_FBW7_1
478:483
PTPPPT
FBXW7
0.8322
More...