DegronMD

Uniprot ID: Q9NZM4

Source protein: BRD4-interacting chromatin-remodeling complex-associated protein

Source gene: BICRA

Class: DEG_SPOP_SBC_1

Location: 983:987

E3 ligase: SPOP

DEGRON score: 0.9317

ASA_SCORE: 93.68

COIL: 0.9146

CONS_SCORE: 0.5271

DSS_SCORE: 0.6209

HELIX: 0.0244

FCONS_SCORE: 1.1856

RIG_SCORE: 0.6629

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N983S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.7069
p.T985P	MFE-319	endometrium	COSMIC	PQTST	DEG_SPOP_SBC_1	0.7031
p.A982S	SIDM00576	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.3056
p.A982S	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.3056
p.A982T	SIDM01612	Endometrial Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.3056
p.A979G	SIDM01045	Endometrial Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.A979G	SIDM00580	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.A979G	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.2222
p.A979G	EN	endometrium	COSMIC	PQTST	DEG_SPOP_SBC_1	0.2222
p.G978A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1944
p.A997V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.0556
p.A997V	SIDM00579	Neuroblastoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.0556
p.A997V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.0556
p.A997V	NB(TU)1-10	autonomic_ganglia	COSMIC	PQTST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons