DegronMD - P30260(CDC27)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L352I	TCGA-06-5416	GBM	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.S390G	TCGA-51-6867	LUSC	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.6993
p.S393Y	TCGA-A2-A0YL	BRCA	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.712
p.T362A	TCGA-AP-A059	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222
p.R214I	TCGA-AP-A059	UCEC	TCGA	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.R214I	DO41361	UCEC	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.K401Q	TCGA-B5-A0JY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1111
p.A379T	TCGA-B5-A0JY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.5
p.A379T	SIDM00382	Glioblastoma	GDSC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.5
p.A379T	ACH-000609	Brain Cancer	CCLE	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.5
p.A379T	SF126	central nervous system	COSMIC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.5
p.V368I	TCGA-B5-A11E	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.5
p.R382Q	TCGA-CA-6718	COAD	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1389
p.R382Q	TCGA-EO-A3AY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1389
p.S390N	TCGA-DF-A2KN	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.7069
p.P366H	TCGA-EB-A24C	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.5556
p.S385L	TCGA-FS-A1ZW	SKCM	TCGA	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.2222
p.Q367H	TCGA-G7-6797	KIRP	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.L352F	TCGA-MT-A67F	HNSC	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.Q367E	TCGA-PG-A914	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.T203M	TCGA-VQ-A924	STAD	TCGA	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7423
p.T203M	DO51795	STAD	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7423
p.I345V	DO221656	ALL	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.I345V	DO229052	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.I345V	DO229062	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.S387Y	DO2903	BRCA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.7222
p.L346I	DO10880	GBM	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1111
p.L346I	DO229035	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1111
p.L346F	DO49070	HNSC	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1111
p.Q361H	DO20917	KIRP	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.25
p.S194C	DO228943	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5556
p.S194C	DO229259	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5556
p.S194C	DO229224	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5556
p.S194C	DO229250	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5556
p.Q348K	DO228950	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.T389N	DO228978	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.7055
p.L215W	DO229030	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1667
p.L215W	DO229052	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1667
p.K390E	DO229052	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.7022
p.K390E	DO229056	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.7022
p.R214G	DO229052	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.I367M	DO229051	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.F382L	DO229056	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1389
p.F382L	DO231356	THCA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1389
p.T356I	DO50771	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7078
p.S384G	DO26477	LUSC	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.6389
p.T368I	DO229494	SKCA	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.5
p.S393R	DO229453	SKCA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation altering degron motif	0.7427
p.S379L	DO37519	SKCM	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.5
p.P360H	DO37438	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.T205I	DO229259	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.8189
p.D208Y	DO229272	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.6214
p.M398K	DO229084	THCA	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.1944
p.V201I	DO231401	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.3056
p.S384N	DO223282	UCEC	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation blocking phosphorylation signal	0.6389
p.K395Q	DO43041	UCEC	ICGC	TKENS	DEG_APCC_KENBOX_2	389:393	Mutation rewiring degron network	0.2778
p.V362I	DO41644	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222
p.Q361E	DO52421	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.25
p.T356A	DO41361	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7139
p.T365I	SIDM00845	Burkitt's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.T365I	ACH-000786	Lymphoma	CCLE	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.T365I	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.P206L	SIDM00454	Rhabdomyosarcoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	ACH-000689	Sarcoma	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	RH-18	soft tissue	COSMIC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.H195Y	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1389
p.H195Y	ACH-000888	Lung Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1389
p.H195Y	NCI-H1793	lung	COSMIC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1389
p.Q207K	SIDM00115	Head and Neck Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.5833
p.Q207K	ACH-002298	Head and Neck Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.5833
p.Q207K	PCI-6A	upper aerodigestive tract	COSMIC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.5833
p.S192C	SIDM00173	Head and Neck Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5
p.S192C	ACH-000618	Head and Neck Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation blocking phosphorylation signal	0.5
p.P366R	ACH-000647	Esophageal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.5556
p.E199Q	ACH-000923	Lymphoma	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.25
p.N213S	ACH-001846	Bile Duct Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2222
p.T359I	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.75
p.T368A	NCI-H2110	lung	COSMIC	PQTST	DEG_SPOP_SBC_1	354:358	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC27

UniProt ID: P30260

Entrez ID: 996

Protein name: Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC27 in