DegronMD

Uniprot ID: P30260

Source protein: Cell division cycle protein 27 homolog

Source gene: CDC27

Class: DEG_SPOP_SBC_1

Location: 354:358

E3 ligase: SPOP

DEGRON score: 0.986

ASA_SCORE: 93.12

COIL: 0.9366

CONS_SCORE: 0.2819

DSS_SCORE: 0.7046

HELIX: 0.029

FCONS_SCORE: 1.1209

RIG_SCORE: 0.5736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L352I	TCGA-06-5416	GBM	TCGA	PQTST	DEG_SPOP_SBC_1	0.2778
p.T362A	TCGA-AP-A059	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.2222
p.V368I	TCGA-B5-A11E	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.5
p.P366H	TCGA-EB-A24C	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.5556
p.Q367H	TCGA-G7-6797	KIRP	TCGA	PQTST	DEG_SPOP_SBC_1	0.0833
p.L352F	TCGA-MT-A67F	HNSC	TCGA	PQTST	DEG_SPOP_SBC_1	0.2778
p.Q367E	TCGA-PG-A914	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.0833
p.I345V	DO221656	ALL	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.I345V	DO229052	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.I345V	DO229062	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.L346I	DO10880	GBM	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.L346I	DO229035	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.L346F	DO49070	HNSC	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.Q361H	DO20917	KIRP	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.Q348K	DO228950	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.1667
p.I367M	DO229051	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.T356I	DO50771	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.7078
p.T368I	DO229494	SKCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.P360H	DO37438	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.2778
p.V362I	DO41644	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.2222
p.Q361E	DO52421	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.T356A	DO41361	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.7139
p.T365I	SIDM00845	Burkitt's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1389
p.T365I	ACH-000786	Lymphoma	CCLE	PQTST	DEG_SPOP_SBC_1	0.1389
p.T365I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.1389
p.P366R	ACH-000647	Esophageal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.5556
p.T359I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.75
p.T368A	NCI-H2110	lung	COSMIC	PQTST	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTST

Degron related mutations and impact score

Drug responses associated with CDC27 mutations

All proteins holding degron of PQTST