DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 2816:2820

E3 ligase: SPOP

DEGRON score: 0.8656

ASA_SCORE: 97.62

COIL: 0.9236

CONS_SCORE: 0.3389

DSS_SCORE: 0.6332

HELIX: 0.0174

FCONS_SCORE: 1.2457

RIG_SCORE: 0.6108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2822L	SIDM00944	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00987	Thyroid Gland Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00776	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00042	Pancreatic Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00284	Melanoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00813	Non-Cancerous	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00631	Breast Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00796	Head and Neck Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00767	Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM00124	Kidney Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778
p.S2822L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons