DegronMD

Uniprot ID: Q9HCS5

Source protein: Band 4.1-like protein 4A

Source gene: EPB41L4A

Class: DEG_SPOP_SBC_1

Location: 658:662

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 86.06

COIL: 0.9114

CONS_SCORE: 0.4083

DSS_SCORE: 0.7077

HELIX: 0.0566

FCONS_SCORE: 1.0505

RIG_SCORE: 0.6551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S661P	TCGA-A6-3808	COAD	TCGA	PQTST	DEG_SPOP_SBC_1	0.6752
p.S661P	DO8408	COAD	ICGC	PQTST	DEG_SPOP_SBC_1	0.6752
p.L665M	TCGA-B5-A11E	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.25
p.L665M	DO233869	GACA	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.L665M	DO41644	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.Q659E	TCGA-BH-A0W7	BRCA	TCGA	PQTST	DEG_SPOP_SBC_1	0.5633
p.Q659E	TCGA-T3-A92M	HNSC	TCGA	PQTST	DEG_SPOP_SBC_1	0.5633
p.Q659E	DO1272	BRCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5633
p.Q659E	DO223269	HNSC	ICGC	PQTST	DEG_SPOP_SBC_1	0.5633
p.G648R	TCGA-D3-A8GI	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.0556
p.G648R	DO50284	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556
p.A671E	DO218890	SKCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.A666V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.K657E	SIDM00580	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.3056
p.K657E	ACH-000168	Leukemia	CCLE	PQTST	DEG_SPOP_SBC_1	0.3056
p.K657E	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.3056
p.S652R	SIDM00943	Pancreatic Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons