DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11695:11699

E3 ligase: SPOP

DEGRON score: 0.8041

ASA_SCORE: 96.06

COIL: 0.8926

CONS_SCORE: 0

DSS_SCORE: 0.5994

HELIX: 0.0126

FCONS_SCORE: 0

RIG_SCORE: 0.6292

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11695Q	TCGA-44-7662	LUAD	TCGA	PQTST	DEG_SPOP_SBC_1	0.7035
p.P11695Q	DO23597	LUAD	ICGC	PQTST	DEG_SPOP_SBC_1	0.7035
p.M11687T	TCGA-AJ-A3EK	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.1111
p.M11687T	DO41584	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.S11709F	TCGA-BF-A1Q0	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	TCGA-D3-A2JN	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO220856	MELA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO220891	MELA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO222521	MELA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO222653	MELA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO222868	MELA	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO47374	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.S11709F	DO47590	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.5
p.P11695L	TCGA-D3-A8GI	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.7582
p.P11695L	DO50284	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.7582
p.S11702F	TCGA-EE-A2GI	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.25
p.S11702F	TCGA-EE-A2GJ	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.25
p.S11702F	DO37746	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.S11702F	DO37410	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.25
p.W11690C	TCGA-FS-A1ZG	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.1944
p.W11690C	DO37523	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.1944
p.S11707R	TCGA-IN-A6RN	STAD	TCGA	PQTST	DEG_SPOP_SBC_1	0.1111
p.S11707R	DO51739	STAD	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.T11697A	TCGA-QK-A8Z9	HNSC	TCGA	PQTST	DEG_SPOP_SBC_1	0.7139
p.T11697A	DO52098	HNSC	ICGC	PQTST	DEG_SPOP_SBC_1	0.7139
p.T11697A	ACH-000982	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.7139
p.T11697A	ACH-001345	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.7139
p.T11697A	GP5d	large_intestine	COSMIC	PQTST	DEG_SPOP_SBC_1	0.7139
p.F11708L	DO222762	COCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0833
p.M11687V	DO22810	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.D11685H	DO35442	PACA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556
p.A11688S	SIDM00570	Gastric Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1389
p.A11688S	ACH-000674	Gastric Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.1389
p.A11688S	NUGC-4	stomach	COSMIC	PQTST	DEG_SPOP_SBC_1	0.1389
p.P11694L	SIDM00392	Melanoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.3056
p.P11694L	ACH-000810	Skin Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.3056
p.P11694L	SK-MEL-30	skin	COSMIC	PQTST	DEG_SPOP_SBC_1	0.3056
p.T11686R	ACH-001611	Brain Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PQTST