DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_SPOP_SBC_1

Location: 1556:1560

E3 ligase: SPOP

DEGRON score: 0.915

ASA_SCORE: 85.1

COIL: 0.9282

CONS_SCORE: 0.258

DSS_SCORE: 0.8486

HELIX: 0.0506

FCONS_SCORE: 0.9042

RIG_SCORE: 0.5574

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1562A	DO224740	PACA	ICGC	PQTST	DEG_SPOP_SBC_1	0.2778
p.K1570N	TCGA-AP-A0LM	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.0556
p.K1570N	DO48414	BLCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556
p.K1570N	DO43306	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 4 of 4 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons