DegronMD

Uniprot ID: Q9BY84

Source protein: Dual specificity protein phosphatase 16

Source gene: DUSP16

Class: DEG_SPOP_SBC_1

Location: 546:550

E3 ligase: SPOP

DEGRON score: 0.5136

ASA_SCORE: 82.42

COIL: 0.933

CONS_SCORE: 0.222

DSS_SCORE: 0.2366

HELIX: 0.0198

FCONS_SCORE: 1.0589

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S549C	TCGA-21-1082	LUSC	TCGA	PQTST	DEG_SPOP_SBC_1	0.7541
p.S549C	DO26463	LUSC	ICGC	PQTST	DEG_SPOP_SBC_1	0.7541
p.L536I	TCGA-A5-A0G2	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.0556
p.L536I	DO41235	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556
p.S541L	TCGA-CG-4305	STAD	TCGA	PQTST	DEG_SPOP_SBC_1	0.1944
p.S541L	DO38823	STAD	ICGC	PQTST	DEG_SPOP_SBC_1	0.1944
p.L536F	TCGA-FS-A1ZA	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	0.0556
p.L536F	DO37551	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	0.0556
p.W539L	DO222864	COCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.1389
p.T548N	DO229036	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.7055
p.D542A	SIDM01096	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00983	Bladder Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00310	Mesothelioma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00732	Glioblastoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM00665	Gastric Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM01012	Other Blood Cancers	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.D542A	SIDM01743	Melanoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.2222
p.K537M	SIDM00660	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1944
p.K537M	ACH-000985	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.1944
p.K537M	LS-411N	large_intestine	COSMIC	PQTST	DEG_SPOP_SBC_1	0.1944
p.L553P	ACH-001786	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons