DegronMD

Uniprot ID: Q9HCJ0

Source protein: Trinucleotide repeat-containing gene 6C protein

Source gene: TNRC6C

Class: DEG_SPOP_SBC_1

Location: 162:166

E3 ligase: SPOP

DEGRON score: 0.818

ASA_SCORE: 93.68

COIL: 0.9182

CONS_SCORE: 0.3037

DSS_SCORE: 0.7371

HELIX: 0.0638

FCONS_SCORE: 0.8866

RIG_SCORE: 0.6318

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P162L	TCGA-A5-A0G2	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	0.7582
p.P162L	DO41235	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	0.7582
p.T164M	TCGA-A8-A07W	BRCA	TCGA	PQTST	DEG_SPOP_SBC_1	0.7423
p.T164M	DO1297	BRCA	ICGC	PQTST	DEG_SPOP_SBC_1	0.7423
p.E162K	NCI-H441	lung	COSMIC	PQTST	DEG_SPOP_SBC_1	0.7022
p.S167Y	TCGA-AA-3984	COAD	TCGA	PQTST	DEG_SPOP_SBC_1	0.3056
p.S167Y	DO9002	COAD	ICGC	PQTST	DEG_SPOP_SBC_1	0.3056
p.E158K	TCGA-FU-A23L	CESC	TCGA	PQTST	DEG_SPOP_SBC_1	0.2222
p.E158K	DO6278	CESC	ICGC	PQTST	DEG_SPOP_SBC_1	0.2222
p.V170L	DO228976	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.2222
p.S171Y	TCGA-AG-A002	READ	TCGA	PQTST	DEG_SPOP_SBC_1	0.1944
p.A174S	DO229026	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	SIDM00845	Burkitt's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	SIDM00461	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	SIDM01519	Head and Neck Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	ACH-000786	Lymphoma	CCLE	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	ACH-000992	Head and Neck Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.1111
p.A174V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	0.1111
p.P176L	ACH-001378	Pancreatic Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS5	Band 4.1-like protein 4A	DEG_SPOP_SBC_1	658:662	PQTST	SPOP	0.9935	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	983:987	PQTST	SPOP	0.9317	More...
P30260	Cell division cycle protein 27 homolog	DEG_SPOP_SBC_1	354:358	PQTST	SPOP	0.986	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	546:550	PQTST	SPOP	0.5136	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10452:10456	PQTST	SPOP	0.5496	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11695:11699	PQTST	SPOP	0.8041	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2264:2268	PQTST	SPOP	0.5315	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2816:2820	PQTST	SPOP	0.8656	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3803:3807	PQTST	SPOP	0.8196	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3819:3823	PQTST	SPOP	0.7188	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	1556:1560	PQTST	SPOP	0.915	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	162:166	PQTST	SPOP	0.818	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons