DegronMD - Q9HCS5(EPB41L4A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S661P	TCGA-A6-3808	COAD	TCGA	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.6752
p.S661P	DO8408	COAD	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.6752
p.E378Q	TCGA-AA-3684	COAD	TCGA	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.6744
p.E378Q	DO8802	COAD	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.6744
p.E375K	TCGA-AP-A0LM	UCEC	TCGA	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.7022
p.E375K	DO43306	UCEC	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.7022
p.L665M	TCGA-B5-A11E	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.L665M	DO233869	GACA	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.L665M	DO41644	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.Q659E	TCGA-BH-A0W7	BRCA	TCGA	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5633
p.Q659E	TCGA-T3-A92M	HNSC	TCGA	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5633
p.Q659E	DO1272	BRCA	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5633
p.Q659E	DO223269	HNSC	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5633
p.G648R	TCGA-D3-A8GI	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.G648R	DO50284	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.S366T	DO229010	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.S366T	DO229013	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.S366T	DO229016	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.S366T	DO229003	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.S366T	DO229005	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.N373K	DO228948	LICA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation altering degron motif	0.6918
p.S366R	DO229028	LICA	ICGC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation blocking phosphorylation signal	0.5833
p.A671E	DO218890	SKCA	ICGC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0833
p.A666V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.2222
p.T371N	SIDM00806	Osteosarcoma	GDSC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.T371N	ACH-000613	Bone Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.T371N	ACH-001001	Bone Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.T371N	HOS	bone	COSMIC	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.2778
p.K657E	SIDM00580	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.3056
p.K657E	ACH-000168	Leukemia	CCLE	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.3056
p.K657E	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.3056
p.S652R	SIDM00943	Pancreatic Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	658:662	Mutation blocking phosphorylation signal	0.6111
p.A387G	ACH-001648	Prostate Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	373:378	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L4A

UniProt ID: Q9HCS5

Entrez ID: 64097

Protein name: Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L4A in