DegronMD

Uniprot ID: Q9HCS5

Source protein: Band 4.1-like protein 4A

Source gene: EPB41L4A

Class: DEG_Kelch_Keap1_1

Location: 373:378

E3 ligase: KEAP1

DEGRON score: 0.9986

ASA_SCORE: 98.6667

COIL: 0.8033

CONS_SCORE: 0.4384

DSS_SCORE: 0.5238

HELIX: 0.1512

FCONS_SCORE: 1.004

RIG_SCORE: 0.6573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E378Q	TCGA-AA-3684	COAD	TCGA	NMENGE	DEG_Kelch_Keap1_1	0.6744
p.E378Q	DO8802	COAD	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.6744
p.E375K	TCGA-AP-A0LM	UCEC	TCGA	NMENGE	DEG_Kelch_Keap1_1	0.7022
p.E375K	DO43306	UCEC	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.7022
p.S366T	DO229010	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.S366T	DO229013	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.S366T	DO229016	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.S366T	DO229003	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.S366T	DO229005	COCA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.N373K	DO228948	LICA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.6918
p.S366R	DO229028	LICA	ICGC	NMENGE	DEG_Kelch_Keap1_1	0.5833
p.T371N	SIDM00806	Osteosarcoma	GDSC	NMENGE	DEG_Kelch_Keap1_1	0.2778
p.T371N	ACH-000613	Bone Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	0.2778
p.T371N	ACH-001001	Bone Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	0.2778
p.T371N	HOS	bone	COSMIC	NMENGE	DEG_Kelch_Keap1_1	0.2778
p.A387G	ACH-001648	Prostate Cancer	CCLE	NMENGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCS5	Band 4.1-like protein 4A	DEG_Kelch_Keap1_1	373:378	NMENGE	KEAP1	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons