DegronMD - Q9BY84(DUSP16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S549C	TCGA-21-1082	LUSC	TCGA	PQTST	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7541
p.S549C	DO26463	LUSC	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7541
p.L536I	TCGA-A5-A0G2	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.L536I	DO41235	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.R505Q	TCGA-AA-3977	COAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.R505Q	TCGA-AX-A05Z	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.R505Q	TCGA-BR-8680	STAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.R505Q	DO8730	COAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.R505Q	DO47769	STAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.R505Q	DO40884	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.V509M	TCGA-BG-A187	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.V509M	TCGA-IB-7651	PAAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.V509M	DO46657	PAAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.V509M	DO41983	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.L499P	TCGA-BR-8368	STAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6471
p.L499P	DO47981	STAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6471
p.S541L	TCGA-CG-4305	STAD	TCGA	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.1944
p.S541L	DO38823	STAD	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.1944
p.S642L	TCGA-CR-6481	HNSC	TCGA	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6556
p.S642L	DO14990	HNSC	ICGC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6556
p.G647R	TCGA-EB-A1NK	SKCM	TCGA	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6457
p.G647R	DO37695	SKCM	ICGC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6457
p.E634K	TCGA-EE-A3JE	SKCM	TCGA	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1111
p.E634K	DO48766	SKCM	ICGC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1111
p.P502A	TCGA-FD-A3SN	BLCA	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6392
p.P502A	DO490	BLCA	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6392
p.S508N	TCGA-FI-A2D0	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.2222
p.S508N	DO43891	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.2222
p.L536F	TCGA-FS-A1ZA	SKCM	TCGA	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.L536F	DO37551	SKCM	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.0556
p.S656L	TCGA-VQ-A8P2	STAD	TCGA	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1667
p.S656L	DO222677	ESCA	ICGC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1667
p.S656L	DO51761	STAD	ICGC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1667
p.W539L	DO222864	COCA	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.1389
p.T548N	DO229036	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation altering degron motif	0.7055
p.D542A	SIDM01096	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00983	Bladder Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00310	Mesothelioma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00732	Glioblastoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM00665	Gastric Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM01012	Other Blood Cancers	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.D542A	SIDM01743	Melanoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.2222
p.H485R	SIDM00128	Head and Neck Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778
p.H485R	ACH-002249	Head and Neck Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778
p.H485R	JHU-011	upper aerodigestive tract	COSMIC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.2778
p.K537M	SIDM00660	Colorectal Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation substituting flanking lysine	0.1944
p.K537M	ACH-000985	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	546:550	Mutation substituting flanking lysine	0.1944
p.K537M	LS-411N	large intestine	COSMIC	PQTST	DEG_SPOP_SBC_1	546:550	Mutation substituting flanking lysine	0.1944
p.L499R	SIDM00481	Ovarian Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7316
p.L499R	ACH-000116	Ovarian Cancer	CCLE	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7316
p.L499R	OAW-28	ovary	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7316
p.S486L	SIDM00475	Ovarian Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.S486L	SIDM00475	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.S486L	SIDM01134	Small Cell Lung Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.S486L	SIDM01134	Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.S486L	OV-56	ovary	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.S486L	OV-56	ovary	COSMIC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.S486L	NCI-H841	lung	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.S486L	NCI-H841	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	487:491	Mutation rewiring degron network	0.3056
p.E644G	SIDM00959	Acute Myeloid Leukemia	GDSC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6087
p.E644G	ACH-000641	Leukemia	CCLE	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6087
p.E644G	ACH-001036	Leukemia	CCLE	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6087
p.E644G	CMK	haematopoietic and lymphoid tissue	COSMIC	SREELGKVG	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6087
p.L500S	ACH-000982	Colon/Colorectal Cancer	CCLE	QRSLLSPLH	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7667
p.L553P	ACH-001786	Colon/Colorectal Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	546:550	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP16

UniProt ID: Q9BY84

Entrez ID: 80824

Protein name: Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP16 in