DegronMD

Uniprot ID: Q9BY84

Source protein: Dual specificity protein phosphatase 16

Source gene: DUSP16

Class: DEG_APCC_DBOX_1

Location: 642:650

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7589

ASA_SCORE: 76.2333

COIL: 0.4831

CONS_SCORE: 0.2352

DSS_SCORE: 0.5396

HELIX: 0.4721

FCONS_SCORE: 1.0745

RIG_SCORE: 0.6785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S642L	TCGA-CR-6481	HNSC	TCGA	SREELGKVG	DEG_APCC_DBOX_1	0.6556
p.S642L	DO14990	HNSC	ICGC	SREELGKVG	DEG_APCC_DBOX_1	0.6556
p.G647R	TCGA-EB-A1NK	SKCM	TCGA	SREELGKVG	DEG_APCC_DBOX_1	0.6457
p.G647R	DO37695	SKCM	ICGC	SREELGKVG	DEG_APCC_DBOX_1	0.6457
p.E634K	TCGA-EE-A3JE	SKCM	TCGA	SREELGKVG	DEG_APCC_DBOX_1	0.1111
p.E634K	DO48766	SKCM	ICGC	SREELGKVG	DEG_APCC_DBOX_1	0.1111
p.S656L	TCGA-VQ-A8P2	STAD	TCGA	SREELGKVG	DEG_APCC_DBOX_1	0.1667
p.S656L	DO222677	ESCA	ICGC	SREELGKVG	DEG_APCC_DBOX_1	0.1667
p.S656L	DO51761	STAD	ICGC	SREELGKVG	DEG_APCC_DBOX_1	0.1667
p.E644G	SIDM00959	Acute Myeloid Leukemia	GDSC	SREELGKVG	DEG_APCC_DBOX_1	0.6087
p.E644G	ACH-000641	Leukemia	CCLE	SREELGKVG	DEG_APCC_DBOX_1	0.6087
p.E644G	ACH-001036	Leukemia	CCLE	SREELGKVG	DEG_APCC_DBOX_1	0.6087
p.E644G	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	SREELGKVG	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY84	Dual specificity protein phosphatase 16	DEG_APCC_DBOX_1	642:650	SREELGKVG	APC,CDC20,FZR1	0.7589	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons