DegronMD

Uniprot ID: Q9BY84

Source protein: Dual specificity protein phosphatase 16

Source gene: DUSP16

Class: DEG_APCC_DBOX_1

Location: 496:504

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9521

ASA_SCORE: 87.8444

COIL: 0.7174

CONS_SCORE: 0.2436

DSS_SCORE: 0.5564

HELIX: 0.2253

FCONS_SCORE: 1.158

RIG_SCORE: 0.6638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R505Q	TCGA-AA-3977	COAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.R505Q	TCGA-AX-A05Z	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.R505Q	TCGA-BR-8680	STAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.R505Q	DO8730	COAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.R505Q	DO47769	STAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.R505Q	DO40884	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.3056
p.V509M	TCGA-BG-A187	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.1944
p.V509M	TCGA-IB-7651	PAAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.1944
p.V509M	DO46657	PAAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.1944
p.V509M	DO41983	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.1944
p.L499P	TCGA-BR-8368	STAD	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.6471
p.L499P	DO47981	STAD	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.6471
p.P502A	TCGA-FD-A3SN	BLCA	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.6392
p.P502A	DO490	BLCA	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.6392
p.S508N	TCGA-FI-A2D0	UCEC	TCGA	QRSLLSPLH	DEG_APCC_DBOX_1	0.2222
p.S508N	DO43891	UCEC	ICGC	QRSLLSPLH	DEG_APCC_DBOX_1	0.2222
p.L499R	SIDM00481	Ovarian Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	0.7316
p.L499R	ACH-000116	Ovarian Cancer	CCLE	QRSLLSPLH	DEG_APCC_DBOX_1	0.7316
p.L499R	OAW-28	ovary	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	0.7316
p.S486L	SIDM00475	Ovarian Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	0.0556
p.S486L	SIDM01134	Small Cell Lung Carcinoma	GDSC	QRSLLSPLH	DEG_APCC_DBOX_1	0.0556
p.S486L	OV-56	ovary	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	0.0556
p.S486L	NCI-H841	lung	COSMIC	QRSLLSPLH	DEG_APCC_DBOX_1	0.0556
p.L500S	ACH-000982	Colon/Colorectal Cancer	CCLE	QRSLLSPLH	DEG_APCC_DBOX_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY84	Dual specificity protein phosphatase 16	DEG_APCC_DBOX_1	496:504	QRSLLSPLH	APC,CDC20,FZR1	0.9521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons