DegronMD

Uniprot ID: P30260

Source protein: Cell division cycle protein 27 homolog

Source gene: CDC27

Class: DEG_APCC_KENBOX_2

Location: 389:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9986

ASA_SCORE: 108.02

COIL: 0.8038

CONS_SCORE: 0.2958

DSS_SCORE: 0.6553

HELIX: 0.1918

FCONS_SCORE: 1.0554

RIG_SCORE: 0.6568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S390G	TCGA-51-6867	LUSC	TCGA	TKENS	DEG_APCC_KENBOX_2	0.6993
p.S393Y	TCGA-A2-A0YL	BRCA	TCGA	TKENS	DEG_APCC_KENBOX_2	0.712
p.K401Q	TCGA-B5-A0JY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	0.1111
p.A379T	TCGA-B5-A0JY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	0.5
p.A379T	SIDM00382	Glioblastoma	GDSC	TKENS	DEG_APCC_KENBOX_2	0.5
p.A379T	ACH-000609	Brain Cancer	CCLE	TKENS	DEG_APCC_KENBOX_2	0.5
p.A379T	SF126	central_nervous_system	COSMIC	TKENS	DEG_APCC_KENBOX_2	0.5
p.R382Q	TCGA-CA-6718	COAD	TCGA	TKENS	DEG_APCC_KENBOX_2	0.1389
p.R382Q	TCGA-EO-A3AY	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	0.1389
p.S390N	TCGA-DF-A2KN	UCEC	TCGA	TKENS	DEG_APCC_KENBOX_2	0.7069
p.S385L	TCGA-FS-A1ZW	SKCM	TCGA	TKENS	DEG_APCC_KENBOX_2	0.2222
p.S387Y	DO2903	BRCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7222
p.T389N	DO228978	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7055
p.K390E	DO229052	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7022
p.K390E	DO229056	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7022
p.F382L	DO229056	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.1389
p.F382L	DO231356	THCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.1389
p.S384G	DO26477	LUSC	ICGC	TKENS	DEG_APCC_KENBOX_2	0.6389
p.S393R	DO229453	SKCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7427
p.S379L	DO37519	SKCM	ICGC	TKENS	DEG_APCC_KENBOX_2	0.5
p.M398K	DO229084	THCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.1944
p.S384N	DO223282	UCEC	ICGC	TKENS	DEG_APCC_KENBOX_2	0.6389
p.K395Q	DO43041	UCEC	ICGC	TKENS	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_APCC_KENBOX_2	389:393	TKENS	APC,CDC20,FZR1	0.9986	More...
Q96P31	Fc receptor-like protein 3	DEG_APCC_KENBOX_2	671:675	TKENS	APC,CDC20,FZR1	0.6978	More...
H0YL09	Putative ubiquitin-conjugating enzyme E2Q2-like protein	DEG_APCC_KENBOX_2	107:111	TKENS	APC,CDC20,FZR1	0.7898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons