DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TKENS
Uniprot ID:
H0YL09
Source protein:
Putative ubiquitin-conjugating enzyme E2Q2-like protein
Source gene:
UBE2Q2L
Class:
DEG_APCC_KENBOX_2
Location:
107:111
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7898
ASA_SCORE:
83.88
COIL:
0.7282
CONS_SCORE:
0
DSS_SCORE:
0.3694
HELIX:
0.2604
FCONS_SCORE:
0
RIG_SCORE:
0.7383
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with UBE2Q2L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TKENS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P30260
Cell division cycle protein 27 homolog
DEG_APCC_KENBOX_2
389:393
TKENS
APC,CDC20,FZR1
0.9986
More...
Q96P31
Fc receptor-like protein 3
DEG_APCC_KENBOX_2
671:675
TKENS
APC,CDC20,FZR1
0.6978
More...
H0YL09
Putative ubiquitin-conjugating enzyme E2Q2-like protein
DEG_APCC_KENBOX_2
107:111
TKENS
APC,CDC20,FZR1
0.7898
More...