FCRL3
UniProt ID: Q96P31
Entrez ID: 115352
Protein name: Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell ...
FUNCTION: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). {ECO:0000269|PubMed:19494275, ECO:0000269|PubMed:19843936, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:23857366}.
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GO - Biological processes (BP):
cell surface receptor signaling pathway [GO:0007166]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; posi...
cell surface receptor signaling pathway [GO:0007166]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]
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GO - Molecular function (MF):
kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]...
kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; transmembrane signaling receptor activity [GO:0004888]
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GO - Cellular component (CC):
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]...
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]
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FCRL3
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Kaplan plot for FCRL3 in
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*NOTE: the Kaplan plots were collected from OncoLnc