DegronMD

Uniprot ID: Q96P31

Source protein: Fc receptor-like protein 3

Source gene: FCRL3

Class: DEG_APCC_KENBOX_2

Location: 671:675

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6978

ASA_SCORE: 103.68

COIL: 0.8402

CONS_SCORE: 0.2754

DSS_SCORE: 0.4412

HELIX: 0.0956

FCONS_SCORE: 1.2364

RIG_SCORE: 0.7061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I661V	TCGA-D8-A1JG	BRCA	TCGA	TKENS	DEG_APCC_KENBOX_2	0.0556
p.I661V	DO1256	BRCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.0556
p.W666L	TCGA-EE-A2MK	SKCM	TCGA	TKENS	DEG_APCC_KENBOX_2	0.1944
p.W666L	DO38177	SKCM	ICGC	TKENS	DEG_APCC_KENBOX_2	0.1944
p.Q669H	DO6362	CLLE	ICGC	TKENS	DEG_APCC_KENBOX_2	0.2778
p.H670Q	DO228385	LICA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.3056
p.Q683E	DO23170	LINC	ICGC	TKENS	DEG_APCC_KENBOX_2	0.1111
p.K672I	DO219878	SKCA	ICGC	TKENS	DEG_APCC_KENBOX_2	0.7531

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_APCC_KENBOX_2	389:393	TKENS	APC,CDC20,FZR1	0.9986	More...
Q96P31	Fc receptor-like protein 3	DEG_APCC_KENBOX_2	671:675	TKENS	APC,CDC20,FZR1	0.6978	More...
H0YL09	Putative ubiquitin-conjugating enzyme E2Q2-like protein	DEG_APCC_KENBOX_2	107:111	TKENS	APC,CDC20,FZR1	0.7898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons